How far is Mayo, FL from Cape Coral, FL?
The driving distance from Mayo, FL to Cape Coral, FL is about 313.4 miles (504.3 km), with a travel time of about 05h 03m by car.
- The straight-line flight distance is about 252.4 miles (406.2 km).
- For a round trip, plan for roughly 10h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 03m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Pasco County, Florida, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Mostly Sunny then Scattered Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Mayo and Cape Coral.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mayo and Cape Coral.
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1
Start on Main Street
1.1 km · 1 min · Main Street
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2
Continue on US Highway 27
40.3 mi · 54 min · US Highway 27
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3
Continue on Northeast 1st Avenue
3011 ft · 1 min · Northeast 1st Avenue
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4
Turn right onto Santa Fe Boulevard
1.4 km · 1 min · Santa Fe Boulevard
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5
Continue on ML King Memorial Highway
3.8 mi · 5 min · ML King Memorial Highway
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6
Take the ramp slight right toward I 75 South: Tampa
1.3 km · 1 min
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7
Merge slight left
124.2 mi · 2 hr 13 min
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8
Keep slight left to continue on South I 75: Naples
74.3 mi · 1 hr 20 min
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9
Keep slight left
42.2 mi · 45 min
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10
Take the exit slight right toward CR 762: North Fort Myers, Cape Coral
1532 ft · 37 sec
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11
Keep slight right to continue on CR 762 West, to US 41
859 ft · 21 sec
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12
Turn straight onto Tuckers Grade
1.4 km · 2 min · Tuckers Grade
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13
Turn left onto Tamiami Trail
10.4 mi · 13 min · Tamiami Trail
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14
Turn right onto Del Prado Boulevard North
6.5 mi · 11 min · Del Prado Boulevard North
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15
Continue on Del Prado Boulevard South
6.2 mi · 13 min · Del Prado Boulevard South
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16
Turn right onto Cape Coral Parkway East
1669 ft · 41 sec · Cape Coral Parkway East
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17
Turn right
61 m · 15 sec
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18
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Mayo and Cape Coral.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 75 South
Merge slight left
124 mi · 02h 13m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Mayo and Mostly Sunny then Scattered Showers And Thunderstorms near Cape Coral.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mayo to Cape Coral?
The road trip is about 313.4 miles (504.3 km) and usually takes 05h 03m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
San Antonio is a useful midpoint, sitting about 156.5 miles from Mayo and 156.8 miles from Cape Coral.
How much longer is the road route than the straight-line distance?
The direct path is about 252.4 miles (406.2 km), while the road route adds roughly 61 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:52 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.88 one way or $91.75 round trip. Estimated CO2 is about 98.3 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Mayo and Mostly Sunny then Scattered Showers And Thunderstorms near Cape Coral.
Stop Ideas Near San Antonio
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to San Antonio.
Dade City, Florida
Lakeland
Lakeland
Union Station
Flight Path Map
This map shows the direct air route between Mayo and Cape Coral. Straight-line distance: 252.39 mi (406.19 km).
#1 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
#2 Cape Coral
The second most populous city in Lee County, Florida.
| Population | 200,972 |
| Coordinates | 26.5628500, -81.9495300 |
| Altitude | 1 |
| Country | United States |
End: (-81.94953, 26.562855)
Estimated Travel Time
Distance: 504 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 26m |
| 40 mph (64.37 km/h) | 07h 50m |
| 50 mph (80.47 km/h) | 06h 16m |
| 60 mph (96.56 km/h) | 05h 13m |
| 70 mph (112.65 km/h) | 04h 28m |
| 80 mph (129 km/h) | 03h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $45.88 | $91.75 |
| Mid-grade | $4.60 | $50.83 | $101.66 |
| Premium | $4.90 | $54.15 | $108.30 |
| Diesel | $4.35 | $48.11 | $96.22 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 26, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.