How far is Cape Coral, FL from Mayo, FL?
The driving distance from Cape Coral, FL to Mayo, FL is about 312.9 miles (503.5 km), with a travel time of about 06h 04m by car.
- The straight-line flight distance is about 252.4 miles (406.2 km).
- For a round trip, plan for roughly 12h 08m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 04m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Pasco County, Florida, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Scattered Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Cape Coral and Mayo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Coral and Mayo.
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1
Start on the route
29 m · 7 sec
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2
Turn right onto Cape Coral Parkway East
38 m · 7 sec · Cape Coral Parkway East
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3
Turn right onto Vincennes Boulevard
109 m · 13 sec · Vincennes Boulevard
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4
Enter the roundabout and take exit 2 toward Vincennes Boulevard
19 m · 2 sec · Vincennes Boulevard
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5
Exit the roundabout onto Vincennes Boulevard
2436 ft · 1 min · Vincennes Boulevard
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6
Turn right onto Coronado Parkway
1 km · 2 min · Coronado Parkway
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7
Turn left onto Del Prado Boulevard South
5.2 mi · 11 min · Del Prado Boulevard South
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8
Continue on Del Prado Boulevard North
6.5 mi · 11 min · Del Prado Boulevard North
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9
Turn left onto North Tamiami Trail
10.4 mi · 13 min · North Tamiami Trail
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10
Turn right onto Tuckers Grade
1.1 mi · 2 min · Tuckers Grade
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11
Take the ramp slight left toward I 75 North: Tampa
2299 ft · 56 sec
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12
Merge slight left
241.4 mi · 4 hr 20 min
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13
Take the exit slight right toward US 441: Alachua, High Springs
1040 ft · 59 sec
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14
Turn right onto ML King Memorial Highway
4 mi · 5 min · ML King Memorial Highway
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15
Continue on Santa Fe Boulevard
1.4 km · 1 min · Santa Fe Boulevard
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16
Turn slight left onto Northeast 1st Avenue
3020 ft · 1 min · Northeast 1st Avenue
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17
Continue on Northwest 1st Avenue
40.3 mi · 54 min · Northwest 1st Avenue
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18
Continue on Main Street
1.1 km · 1 min · Main Street
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19
Arrive at your destination
0 m · 1 sec · Main Street
Car Route Details
A richer read on the saved driving route between Cape Coral and Mayo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 75 North
Merge slight left
241 mi · 04h 20m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny then Scattered Showers And Thunderstorms leaving Cape Coral and Chance Showers And Thunderstorms near Mayo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Coral to Mayo?
The road trip is about 312.9 miles (503.5 km) and usually takes 06h 04m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
San Antonio is a useful midpoint, sitting about 156.7 miles from Cape Coral and 156.2 miles from Mayo.
How much longer is the road route than the straight-line distance?
The direct path is about 252.4 miles (406.2 km), while the road route adds roughly 60.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.79 one way or $91.59 round trip. Estimated CO2 is about 98.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Scattered Showers And Thunderstorms around Cape Coral and Chance Showers And Thunderstorms near Mayo.
Stop Ideas Near San Antonio
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to San Antonio.
Dade City, Florida
Lakeland
Lakeland
Union Station
Flight Path Map
This map shows the direct air route between Cape Coral and Mayo. Straight-line distance: 252.39 mi (406.19 km).
#1 Cape Coral
The second most populous city in Lee County, Florida.
| Population | 200,972 |
| Coordinates | 26.5628500, -81.9495300 |
| Altitude | 1 |
| Country | United States |
#2 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
End: Mayo (-83.17486, 30.053)
Estimated Travel Time
Distance: 504 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 25m |
| 40 mph (64.37 km/h) | 07h 49m |
| 50 mph (80.47 km/h) | 06h 15m |
| 60 mph (96.56 km/h) | 05h 12m |
| 70 mph (112.65 km/h) | 04h 28m |
| 80 mph (129 km/h) | 03h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $45.79 | $91.59 |
| Mid-grade | $4.60 | $50.74 | $101.48 |
| Premium | $4.90 | $54.05 | $108.10 |
| Diesel | $4.35 | $48.02 | $96.05 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 26, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.