How far is Mayo, FL from Orlando, FL?
The driving distance from Mayo, FL to Orlando, FL is about 170.9 miles (275.1 km), with a travel time of about 02h 49m by car.
- The straight-line flight distance is about 150.5 miles (242.2 km).
- For a round trip, plan for roughly 05h 38m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM EDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 49m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Marion County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Mayo and Orlando.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mayo and Orlando.
-
1
Start on Main Street
1.1 km · 1 min · Main Street
-
2
Continue on US Highway 27
40.3 mi · 54 min · US Highway 27
-
3
Continue on Northeast 1st Avenue
3011 ft · 1 min · Northeast 1st Avenue
-
4
Turn right onto Santa Fe Boulevard
1.4 km · 1 min · Santa Fe Boulevard
-
5
Continue on ML King Memorial Highway
3.8 mi · 5 min · ML King Memorial Highway
-
6
Take the ramp slight right toward I 75 South: Tampa
1.3 km · 1 min
-
7
Merge slight left
70.8 mi · 1 hr 16 min
-
8
Take the exit slight left toward Florida's Turnpike South, Orlando
42.3 mi · 45 min · Florida's Turnpike
-
9
Take the exit slight right toward FL 408 Toll East: Orlando, Titusville
1.8 mi · 2 min · Spessard L. Holland East-West Expressway
-
10
Continue on East-West Expressway
7.1 mi · 8 min · East-West Expressway
-
11
Take the exit slight right toward US 17, US 92, US 441: Orange Blossom Trail
799 ft · 21 sec
-
12
Continue on Carter Street
3109 ft · 2 min · Carter Street
-
13
Enter the roundabout and take exit 3 toward Hicks Avenue
62 m · 5 sec · Hicks Avenue
-
14
Exit the roundabout onto Hicks Avenue
701 ft · 21 sec · Hicks Avenue
-
15
Turn right onto West Anderson Street
2446 ft · 1 min · West Anderson Street
-
16
Turn left onto Boone Avenue
655 ft · 22 sec · Boone Avenue
-
17
Turn right onto West South Street
60 m · 5 sec · West South Street
-
18
Turn slight right
31 m · 4 sec
-
19
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Mayo and Orlando.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 75 South
Merge slight left
70.8 mi · 01h 16m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Sunny leaving Mayo and Mostly Sunny near Orlando.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mayo to Orlando?
The road trip is about 170.9 miles (275.1 km) and usually takes 02h 49m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Reddick is a useful midpoint, sitting about 85.4 miles from Mayo and 85.6 miles from Orlando.
How much longer is the road route than the straight-line distance?
The direct path is about 150.5 miles (242.2 km), while the road route adds roughly 20.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM EDT. If you want a more comfortable same-day return, try to leave by 12:52 PM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $25.01 one way or $50.02 round trip. Estimated CO2 is about 53.6 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Mayo and Mostly Sunny near Orlando.
Stop Ideas Near Reddick
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Reddick.
Ocala, Florida
Gainesville, Florida
Waldo, Florida
The Villages-Lady Lake, FL
Flight Path Map
This map shows the direct air route between Mayo and Orlando. Straight-line distance: 150.53 mi (242.25 km).
#1 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
#2 Orlando
The most populous city in Florida and the center of the Orlando metropolitan area.
| Population | 289,457 |
| Coordinates | 28.5383400, -81.3792400 |
| Altitude | 30 |
| Country | United States |
End: South Street (-81.379244, 28.538325)
Estimated Travel Time
Distance: 275 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 41m |
| 40 mph (64.37 km/h) | 04h 16m |
| 50 mph (80.47 km/h) | 03h 25m |
| 60 mph (96.56 km/h) | 02h 50m |
| 70 mph (112.65 km/h) | 02h 26m |
| 80 mph (129 km/h) | 02h 07m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $25.01 | $50.02 |
| Mid-grade | $4.60 | $27.71 | $55.43 |
| Premium | $4.90 | $29.52 | $59.05 |
| Diesel | $4.35 | $26.23 | $52.46 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.