How far is Orlando, FL from Mayo, FL?
The driving distance from Orlando, FL to Mayo, FL is about 170.8 miles (274.8 km), with a travel time of about 03h 19m by car.
- The straight-line flight distance is about 150.5 miles (242.2 km).
- For a round trip, plan for roughly 06h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 19m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Marion County, Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Orlando and Mayo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Orlando and Mayo.
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1
Start on the route
35 m · 5 sec
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2
Turn right onto South Orange Avenue
660 ft · 27 sec · South Orange Avenue
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3
Turn straight
73 m · 10 sec
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4
Turn slight right onto Lucerne Circle West
87 m · 13 sec · Lucerne Circle West
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5
Take the ramp slight right toward FL 408 Toll West
1327 ft · 32 sec
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6
Merge slight left onto East-West Expressway
8.2 mi · 10 min · East-West Expressway
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7
Continue on Spessard L. Holland East-West Expressway
1.2 km · 54 sec · Spessard L. Holland East-West Expressway
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8
Keep slight right to continue on Florida's Turnpike North, Ocala
3233 ft · 1 min
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9
Merge slight left onto Florida's Turnpike
42.3 mi · 45 min · Florida's Turnpike
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10
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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11
Merge slight left
71.6 mi · 1 hr 17 min
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12
Take the exit slight right toward US 441: Alachua, High Springs
1040 ft · 59 sec
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13
Turn right onto ML King Memorial Highway
4 mi · 5 min · ML King Memorial Highway
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14
Continue on Santa Fe Boulevard
1.4 km · 1 min · Santa Fe Boulevard
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15
Turn slight left onto Northeast 1st Avenue
3020 ft · 1 min · Northeast 1st Avenue
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16
Continue on Northwest 1st Avenue
40.3 mi · 54 min · Northwest 1st Avenue
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17
Continue on Main Street
1.1 km · 1 min · Main Street
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18
Arrive at your destination
0 m · 1 sec · Main Street
Car Route Details
A richer read on the saved driving route between Orlando and Mayo.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Florida's Turnpike
Merge slight left
71.6 mi · 01h 17m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Orlando and Sunny near Mayo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Orlando to Mayo?
The road trip is about 170.8 miles (274.8 km) and usually takes 03h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Reddick is a useful midpoint, sitting about 85.4 miles from Orlando and 85.3 miles from Mayo.
How much longer is the road route than the straight-line distance?
The direct path is about 150.5 miles (242.2 km), while the road route adds roughly 20.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:20 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $25.01 one way or $50.02 round trip. Estimated CO2 is about 53.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Orlando and Sunny near Mayo.
Stop Ideas Near Reddick
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Reddick.
Ocala, Florida
Gainesville, Florida
Waldo, Florida
The Villages-Lady Lake, FL
Flight Path Map
This map shows the direct air route between Orlando and Mayo. Straight-line distance: 150.53 mi (242.25 km).
#1 Orlando
The most populous city in Florida and the center of the Orlando metropolitan area.
| Population | 289,457 |
| Coordinates | 28.5383400, -81.3792400 |
| Altitude | 30 |
| Country | United States |
#2 Mayo
Municipality in Lafayette, Florida, USA
| Population | 1,289 |
| Coordinates | 30.0530000, -83.1748600 |
| Altitude | 27 |
| Country | United States |
End: Mayo (-83.17486, 30.053)
Estimated Travel Time
Distance: 275 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 41m |
| 40 mph (64.37 km/h) | 04h 16m |
| 50 mph (80.47 km/h) | 03h 24m |
| 60 mph (96.56 km/h) | 02h 50m |
| 70 mph (112.65 km/h) | 02h 26m |
| 80 mph (129 km/h) | 02h 07m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $25.01 | $50.02 |
| Mid-grade | $4.60 | $27.71 | $55.43 |
| Premium | $4.90 | $29.52 | $59.05 |
| Diesel | $4.35 | $26.23 | $52.46 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.