How far is De Soto, MO from Cape Girardeau, MO?
The driving distance from De Soto, MO to Cape Girardeau, MO is about 95.6 miles (153.9 km), with a travel time of about 01h 31m by car.
- The straight-line flight distance is about 80.8 miles (130 km).
- For a round trip, plan for roughly 03h 02m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 31m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Patchy Fog
Driving Route Map
The map below follows the saved road route between De Soto and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Soto and Cape Girardeau.
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1
Start on Easton Street
133 m · 24 sec · Easton Street
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2
At the end of the road, turn left onto North Main Street
1 km · 57 sec · North Main Street
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3
Turn right onto Fountain City Road
1.2 km · 2 min · Fountain City Road
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4
Turn right
4.2 mi · 5 min
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5
Take the ramp left toward US 67 North: Festus, Crystal City
1377 ft · 18 sec
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6
Merge slight left
5.7 mi · 7 min
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7
Keep slight left
571 ft · 8 sec
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8
Enter the roundabout and take exit 2 toward the route
56 m · 3 sec
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9
Exit the roundabout
133 m · 11 sec
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10
Continue on I 55 South: Cape Girardeau
74.7 mi · 1 hr 20 min
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11
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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12
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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13
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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14
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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15
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between De Soto and Cape Girardeau.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Continue on I 55 South: Cape Girardeau
74.7 mi · 01h 20m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Chance Showers And Thunderstorms leaving De Soto and Patchy Fog near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Soto to Cape Girardeau?
The road trip is about 95.6 miles (153.9 km) and usually takes 01h 31m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Saint Mary is a useful midpoint, sitting about 46.3 miles from De Soto and 49.3 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 80.8 miles (130 km), while the road route adds roughly 14.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 3:28 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $12.71 one way or $25.42 round trip. Estimated CO2 is about 29.9 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around De Soto and Patchy Fog near Cape Girardeau.
Stop Ideas Near Saint Mary
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Saint Mary.
Du Quoin
Carbondale station
Gateway Transportation Center
Kirkwood
Flight Path Map
This map shows the direct air route between De Soto and Cape Girardeau. Straight-line distance: 80.8 mi (130.04 km).
#1 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 154 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 11m |
| 40 mph (64.37 km/h) | 02h 23m |
| 50 mph (80.47 km/h) | 01h 54m |
| 60 mph (96.56 km/h) | 01h 35m |
| 70 mph (112.65 km/h) | 01h 21m |
| 80 mph (129 km/h) | 01h 11m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $12.71 | $25.42 |
| Mid-grade | $4.25 | $14.33 | $28.67 |
| Premium | $4.65 | $15.68 | $31.37 |
| Diesel | $5.30 | $17.87 | $35.75 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 31, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.