How far is Cape Girardeau, MO from De Soto, MO?
The driving distance from Cape Girardeau, MO to De Soto, MO is about 92.6 miles (149.1 km), with a travel time of about 01h 46m by car.
- The straight-line flight distance is about 80.8 miles (130 km).
- For a round trip, plan for roughly 03h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 46m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Cloudy then Slight Chance Rain Showers
Driving Route Map
The map below follows the saved road route between Cape Girardeau and De Soto.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and De Soto.
-
1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
-
3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
74.3 mi · 1 hr 20 min
-
5
Take the exit slight right toward US 67 North: Crystal City
1891 ft · 41 sec
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6
Turn slight left
1864 ft · 29 sec
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7
Enter the roundabout and take exit 2 toward the route
47 m · 2 sec
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8
Exit the roundabout
5.9 mi · 7 min
-
9
Take the exit slight right toward MO CC, MO 110: Olympian Village, De Soto
1350 ft · 32 sec
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10
Turn right
4.1 mi · 5 min
-
11
Turn left onto Fountain City Road
1.2 km · 2 min · Fountain City Road
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12
Turn left onto North Main Street
1.1 km · 1 min · North Main Street
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13
Turn right onto Easton Street
133 m · 19 sec · Easton Street
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14
Arrive at your destination
0 m · 1 sec · Easton Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and De Soto.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 North
Merge slight left
74.3 mi · 01h 20m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Sunny leaving Cape Girardeau and Mostly Cloudy then Slight Chance Rain Showers near De Soto.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to De Soto?
The road trip is about 92.6 miles (149.1 km) and usually takes 01h 46m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Saint Mary is a useful midpoint, sitting about 46.3 miles from Cape Girardeau and 46.3 miles from De Soto.
How much longer is the road route than the straight-line distance?
The direct path is about 80.8 miles (130 km), while the road route adds roughly 11.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 2:56 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $12.33 one way or $24.66 round trip. Estimated CO2 is about 29.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Cape Girardeau and Mostly Cloudy then Slight Chance Rain Showers near De Soto.
Stop Ideas Near Saint Mary
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Saint Mary.
Du Quoin
Carbondale station
Gateway Transportation Center
Kirkwood
Flight Path Map
This map shows the direct air route between Cape Girardeau and De Soto. Straight-line distance: 80.8 mi (130.04 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
End: De Soto (-90.55513, 38.1395)
Estimated Travel Time
Distance: 149 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 05m |
| 40 mph (64.37 km/h) | 02h 18m |
| 50 mph (80.47 km/h) | 01h 51m |
| 60 mph (96.56 km/h) | 01h 32m |
| 70 mph (112.65 km/h) | 01h 19m |
| 80 mph (129 km/h) | 01h 09m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $12.33 | $24.66 |
| Mid-grade | $4.25 | $13.91 | $27.81 |
| Premium | $4.65 | $15.22 | $30.44 |
| Diesel | $5.30 | $17.34 | $34.69 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.