How far is Cape Girardeau, MO from Kansas City, MO?
Fastest route
The fastest route from Cape Girardeau, Missouri, USA to Kansas City, Missouri, USA is approximately 349 miles and takes about 5 hours and 8 minutes. The route includes highways such as I-55 N and I-70 W.
Directions
- Get on I-55 N: Head west on Broadway St toward Main St. Pass by Dollar General (on the right in 0.5 mi). Turn right onto N Kingshighway St. Use the right lane to take the ramp onto I-55 N.
- Continue on I-55 N: Drive on I-55 N until you reach I-70 W.
- Take exit 2P: Take exit 2P from I-670 W.
- Merge onto I-64 W/US-40 W/US-61 N: Take exit 196 for I-270 W toward Kansas City. Take exit 12 to merge onto I-64 W/US-40 W/US-61 N toward Wentzville.
- Merge onto I-70 W/US-40 W: Take exit 1A on the left to merge onto I-70 W/US-40 W toward Kansas City.
- Keep left at the fork: Continue on I-70 W. Use the 2nd from the right lane to keep left at the fork.
- Take exit 2P toward 13th St/Downtown: Continue on I-670 W and follow signs for I-70 Alt/I-35 S/Topeka/Wichita/13th St. Take exit 2P toward 13th St/Downtown. Continue on E 13th St to your destination.
Tips & Suggestions
- 🚗 Make sure to follow the directions carefully to stay on the fastest route.
- ⛽ Plan for necessary fuel stops along the way.
- 🍽️ Consider taking breaks for meals or rest at appropriate locations.
- 📱 Use navigation apps or GPS devices to assist you during the journey.
- 🚧 Stay updated on traffic conditions to adjust your route if needed.
- 🛣️ Enjoy the scenic views and attractions along the way.
- 📚 Familiarize yourself with the local traffic regulations and laws.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 15m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Kansas City.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Kansas City.
-
1
Start on Broadway Street
2 mi · 4 min · Broadway Street
-
2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
-
3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
-
4
Merge slight left
95.1 mi · 1 hr 42 min
-
5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
-
6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
-
7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
-
8
Continue on I 270 West
1.2 km · 1 min
-
9
Merge slight left
11.5 mi · 14 min
-
10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
-
11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
-
12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
-
13
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
-
14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
-
15
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
-
16
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
-
17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
-
18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
-
19
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
-
20
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
-
21
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
-
22
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
-
23
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
-
24
Continue on George Brett Super Highway
6.8 mi · 9 min · George Brett Super Highway
-
25
Keep slight left to continue on I 670 West, I 70 Alternate, I 35 South: Topeka, Wichita
1120 ft · 21 sec
-
26
Take the exit slight right toward 13th Street, Downtown
905 ft · 24 sec
-
27
Continue on East 13th Street
1313 ft · 35 sec · East 13th Street
-
28
Turn right onto Oak Street
139 m · 13 sec · Oak Street
-
29
Arrive at your destination
0 m · 1 sec · Oak Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Kansas City.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Cape Girardeau and Mostly Sunny near Kansas City.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Kansas City?
The road trip is about 349.2 miles (562 km) and usually takes 05h 15m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
New Florence is a useful midpoint, sitting about 174.4 miles from Cape Girardeau and 174.9 miles from Kansas City.
How much longer is the road route than the straight-line distance?
The direct path is about 301.4 miles (485 km), while the road route adds roughly 47.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:30 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $46.46 one way or $92.92 round trip. Estimated CO2 is about 109.5 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Cape Girardeau and Mostly Sunny near Kansas City.
Stop Ideas Near New Florence
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to New Florence.
Hermann
Washington
Jefferson City
Kirkwood
Flight Path Map
This map shows the direct air route between Cape Girardeau and Kansas City. Straight-line distance: 301.36 mi (484.99 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Kansas City
The third most populous city in Missouri and the center of the Kansas City metropolitan area.
| Population | 495,327 |
| Coordinates | 39.0997300, -94.5785700 |
| Altitude | 274 |
| Country | United States |
End: Oak Street (-94.578571, 39.099732)
Estimated Travel Time
Distance: 562 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 38m |
| 40 mph (64.37 km/h) | 08h 43m |
| 50 mph (80.47 km/h) | 06h 59m |
| 60 mph (96.56 km/h) | 05h 49m |
| 70 mph (112.65 km/h) | 04h 59m |
| 80 mph (129 km/h) | 04h 21m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $46.46 | $92.92 |
| Mid-grade | $4.25 | $52.40 | $104.79 |
| Premium | $4.65 | $57.34 | $114.67 |
| Diesel | $5.30 | $65.35 | $130.69 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 02, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.