How far is Cape Girardeau, MO from Saint Joseph, MO?
The driving distance from Cape Girardeau, MO to Saint Joseph, MO is about 407 miles (655 km), with a travel time of about 06h 07m by car.
- The straight-line flight distance is about 334.4 miles (538.2 km).
- For a round trip, plan for roughly 12h 15m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 07m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Callaway County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers then Partly Sunny
Partly Sunny
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Saint Joseph.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Saint Joseph.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
11.5 mi · 14 min
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10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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13
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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15
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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16
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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21
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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22
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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23
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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24
Continue on George Brett Super Highway
1.4 km · 58 sec · George Brett Super Highway
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25
Take the exit slight right toward I 435 North, US 24 East: Des Moines
1.1 mi · 2 min
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26
Merge slight left onto Lamar Hunt Memorial Highway
7.8 mi · 9 min · Lamar Hunt Memorial Highway
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27
Continue on I435 N
1.3 mi · 1 min · I435 N
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28
Continue straight
20.9 mi · 22 min
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29
Keep slight left to continue on I 29 North, US 71 North: Saint Joseph
26 mi · 28 min
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30
Take the exit slight right toward I 229 North: Downtown Saint Joseph
2673 ft · 54 sec
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31
Continue straight
5.7 mi · 7 min
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32
Take the exit slight right toward Central Business District
1382 ft · 34 sec
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33
Continue on Edmond Street
2408 ft · 58 sec · Edmond Street
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34
Turn left onto South 10th Street
841 ft · 21 sec · South 10th Street
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35
Turn right onto Frederick Avenue
116 m · 6 sec · Frederick Avenue
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36
Turn slight right onto Walter Welsh Avenue
42 m · 3 sec · Walter Welsh Avenue
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37
Arrive at your destination
0 m · 1 sec · Walter Welsh Avenue
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Saint Joseph.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Slight Chance Rain Showers then Partly Sunny leaving Cape Girardeau and Partly Sunny near Saint Joseph.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Saint Joseph?
The road trip is about 407 miles (655 km) and usually takes 06h 07m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kingdom City is a useful midpoint, sitting about 203.3 miles from Cape Girardeau and 203.7 miles from Saint Joseph.
How much longer is the road route than the straight-line distance?
The direct path is about 334.4 miles (538.2 km), while the road route adds roughly 72.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $54.15 one way or $108.30 round trip. Estimated CO2 is about 127.6 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Rain Showers then Partly Sunny around Cape Girardeau and Partly Sunny near Saint Joseph.
Stop Ideas Near Kingdom City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kingdom City.
Jefferson City
Hermann
Washington
Sedalia
Flight Path Map
This map shows the direct air route between Cape Girardeau and Saint Joseph. Straight-line distance: 334.4 mi (538.17 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Saint Joseph
The most populous city in Buchanan County, Missouri.
| Population | 74,074 |
| Coordinates | 39.7686100, -94.8466300 |
| Altitude | 270 |
| Country | United States |
End: Walter Welsh Avenue (-94.846632, 39.768853)
Estimated Travel Time
Distance: 655 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 33m |
| 40 mph (64.37 km/h) | 10h 10m |
| 50 mph (80.47 km/h) | 08h 08m |
| 60 mph (96.56 km/h) | 06h 46m |
| 70 mph (112.65 km/h) | 05h 48m |
| 80 mph (129 km/h) | 05h 04m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $54.15 | $108.30 |
| Mid-grade | $4.25 | $61.07 | $122.15 |
| Premium | $4.65 | $66.83 | $133.66 |
| Diesel | $5.30 | $76.17 | $152.33 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.