How far is Saint Joseph, MO from Cape Girardeau, MO?
The driving distance from Saint Joseph, MO to Cape Girardeau, MO is about 410.2 miles (660.2 km), with a travel time of about 06h 09m by car.
- The straight-line flight distance is about 334.4 miles (538.2 km).
- For a round trip, plan for roughly 12h 19m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 09m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Callaway County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Saint Joseph and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph and Cape Girardeau.
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1
Start on Walter Welsh Avenue
127 m · 9 sec · Walter Welsh Avenue
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2
Turn right onto North 12th Street
91 m · 10 sec · North 12th Street
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3
Turn right onto Francis Street
1130 ft · 38 sec · Francis Street
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4
Turn left onto North 9th Street
1.2 mi · 2 min · North 9th Street
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5
Take the ramp slight right
741 ft · 16 sec
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6
Merge slight left
929 ft · 20 sec
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7
Take the exit slight left toward I 229 South, US 59 South: Kansas City
992 ft · 21 sec
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8
Merge slight left
4.5 mi · 5 min
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9
Keep slight right to continue on I 29 South, US 71 South: Kansas City
1705 ft · 29 sec
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10
Merge slight left
26.1 mi · 28 min
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11
Merge slight right
2.2 mi · 2 min
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12
Keep slight right to continue on I 435 East: Saint Louis
28 mi · 31 min
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13
Keep slight right to continue on I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
1500 ft · 23 sec
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14
Keep slight left to continue on I 70 East: Saint Louis
1.2 mi · 2 min
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15
Keep slight left to continue on I 70 East: Saint Louis
143 m · 12 sec
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16
Merge slight left onto George Brett Super Highway
2213 ft · 29 sec · George Brett Super Highway
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17
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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18
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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19
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
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20
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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21
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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22
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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23
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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24
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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25
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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26
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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27
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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28
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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29
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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30
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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31
Merge slight left
11.5 mi · 14 min
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32
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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33
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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34
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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35
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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36
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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37
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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38
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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39
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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40
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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41
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Saint Joseph and Cape Girardeau.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny leaving Saint Joseph and Sunny near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Saint Joseph to Cape Girardeau?
The road trip is about 410.2 miles (660.2 km) and usually takes 06h 09m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Kingdom City is a useful midpoint, sitting about 203.1 miles from Saint Joseph and 207.1 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 334.4 miles (538.2 km), while the road route adds roughly 75.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $54.57 one way or $109.13 round trip. Estimated CO2 is about 128.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Saint Joseph and Sunny near Cape Girardeau.
Stop Ideas Near Kingdom City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kingdom City.
Jefferson City
Hermann
Washington
Sedalia
Flight Path Map
This map shows the direct air route between Saint Joseph and Cape Girardeau. Straight-line distance: 334.4 mi (538.17 km).
#1 Saint Joseph
The most populous city in Buchanan County, Missouri.
| Population | 74,074 |
| Coordinates | 39.7686100, -94.8466300 |
| Altitude | 270 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 660 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 40m |
| 40 mph (64.37 km/h) | 10h 15m |
| 50 mph (80.47 km/h) | 08h 12m |
| 60 mph (96.56 km/h) | 06h 50m |
| 70 mph (112.65 km/h) | 05h 51m |
| 80 mph (129 km/h) | 05h 07m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $54.57 | $109.13 |
| Mid-grade | $4.25 | $61.54 | $123.08 |
| Premium | $4.65 | $67.34 | $134.69 |
| Diesel | $5.30 | $76.75 | $153.50 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.