How far is De Soto, MO from O'Fallon, MO?
The driving distance from De Soto, MO to O'Fallon, MO is about 65.9 miles (106.1 km), with a travel time of about 01h 11m by car.
- The straight-line flight distance is about 47 miles (75.7 km).
- For a round trip, plan for roughly 02h 23m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 11m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Saint Louis County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Isolated Showers And Thunderstorms then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between De Soto and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Soto and O'Fallon.
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1
Start on Easton Street
133 m · 24 sec · Easton Street
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2
At the end of the road, turn left onto North Main Street
1.4 mi · 2 min · North Main Street
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3
At the end of the road, turn left
1.5 mi · 2 min
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4
At the end of the road, turn right
124 m · 6 sec
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5
Continue straight
3.8 mi · 5 min
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6
Turn left
1894 ft · 36 sec
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7
Continue on MO 21 North: Saint Louis
19.7 mi · 23 min
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8
Take the exit slight right toward MO 141: Arnold, Fenton
1384 ft · 24 sec
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9
Turn left
4 mi · 6 min
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10
Take the exit right toward MO 30 East: Saint Louis
1229 ft · 17 sec
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11
Merge slight left
2.5 mi · 4 min
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12
Take the exit left toward I 270 North
2202 ft · 35 sec
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13
Merge slight left
14.7 mi · 18 min
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14
Take the exit slight right toward I 70: Kansas City, Saint Louis, Saint Louis Lambert International Airport
1 mi · 1 min
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15
Keep slight left to continue on I 70 West: Kansas City
645 ft · 11 sec
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16
Continue on I 70 West: Kansas City
1 km · 57 sec
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17
Merge slight left
13.6 mi · 17 min
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18
Take the exit slight right toward MO K: O'Fallon, Main Street
119 m · 8 sec
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19
Turn straight onto East Terra Lane
1.4 km · 2 min · East Terra Lane
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20
Turn right onto South Main Street
2830 ft · 1 min · South Main Street
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21
Turn right
8 m · 2 sec
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22
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between De Soto and O'Fallon.
Turn-heavy local drive
The route has frequent decision points for its length, so lane choice and turn timing will matter more than cruising speed.
MO 21 North
Continue on MO 21 North: Saint Louis
19.7 mi · 00h 23m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Chance Showers And Thunderstorms leaving De Soto and Isolated Showers And Thunderstorms then Chance Showers And Thunderstorms near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Soto to O'Fallon?
The road trip is about 65.9 miles (106.1 km) and usually takes 01h 11m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Sunset Hills is a useful midpoint, sitting about 32.9 miles from De Soto and 33 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 47 miles (75.7 km), while the road route adds roughly 18.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 4:06 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $8.79 one way or $17.57 round trip. Estimated CO2 is about 20.7 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around De Soto and Isolated Showers And Thunderstorms then Chance Showers And Thunderstorms near O'Fallon.
Stop Ideas Near Sunset Hills
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Sunset Hills.
Kirkwood
Gateway Transportation Center
Alton
Washington
Flight Path Map
This map shows the direct air route between De Soto and O'Fallon. Straight-line distance: 47.03 mi (75.68 km).
#1 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 106 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 02h 11m |
| 40 mph (64.37 km/h) | 01h 38m |
| 50 mph (80.47 km/h) | 01h 19m |
| 60 mph (96.56 km/h) | 01h 05m |
| 70 mph (112.65 km/h) | 00h 56m |
| 80 mph (129 km/h) | 00h 49m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $8.79 | $17.57 |
| Mid-grade | $4.25 | $9.91 | $19.82 |
| Premium | $4.65 | $10.84 | $21.69 |
| Diesel | $5.30 | $12.36 | $24.72 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 31, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.