How far is De Soto, MO from Saint Joseph, MO?
The driving distance from De Soto, MO to Saint Joseph, MO is about 334.3 miles (538 km), with a travel time of about 05h 08m by car.
- The straight-line flight distance is about 256.6 miles (412.9 km).
- For a round trip, plan for roughly 10h 16m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 08m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between De Soto and Saint Joseph.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Soto and Saint Joseph.
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1
Start on Easton Street
133 m · 24 sec · Easton Street
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2
At the end of the road, turn left onto North Main Street
1.4 mi · 2 min · North Main Street
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3
At the end of the road, turn left
1.5 mi · 2 min
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4
At the end of the road, turn right
124 m · 6 sec
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5
Continue straight
3.8 mi · 5 min
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6
Turn left
1894 ft · 36 sec
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7
Continue on MO 21 North: Saint Louis
19.7 mi · 23 min
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8
Take the exit slight right toward MO 141: Arnold, Fenton
1384 ft · 24 sec
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9
Turn left
4 mi · 6 min
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10
Keep slight left to continue on MO 141
11.3 mi · 18 min · MO 141
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11
Take the exit slight left toward I 64 West, US 40 West, US 61 North: Wentzville
41 m · 7 sec
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12
Turn left onto I 64 West, US 40 West, US 61 North: Wentzville
1812 ft · 44 sec
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13
Merge slight left onto Avenue of the Saints
22.1 mi · 27 min · Avenue of the Saints
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14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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15
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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16
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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21
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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22
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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23
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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24
Continue on George Brett Super Highway
1.4 km · 58 sec · George Brett Super Highway
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25
Take the exit slight right toward I 435 North, US 24 East: Des Moines
1.1 mi · 2 min
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26
Merge slight left onto Lamar Hunt Memorial Highway
7.8 mi · 9 min · Lamar Hunt Memorial Highway
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27
Continue on I435 N
1.3 mi · 1 min · I435 N
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28
Continue straight
20.9 mi · 22 min
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29
Keep slight left to continue on I 29 North, US 71 North: Saint Joseph
26 mi · 28 min
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30
Take the exit slight right toward I 229 North: Downtown Saint Joseph
2673 ft · 54 sec
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31
Continue straight
5.7 mi · 7 min
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32
Take the exit slight right toward Central Business District
1382 ft · 34 sec
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33
Continue on Edmond Street
2408 ft · 58 sec · Edmond Street
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34
Turn left onto South 10th Street
841 ft · 21 sec · South 10th Street
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35
Turn right onto Frederick Avenue
116 m · 6 sec · Frederick Avenue
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36
Turn slight right onto Walter Welsh Avenue
42 m · 3 sec · Walter Welsh Avenue
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37
Arrive at your destination
0 m · 1 sec · Walter Welsh Avenue
Car Route Details
A richer read on the saved driving route between De Soto and Saint Joseph.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Dwight D Eisenhower Highway
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving De Soto and Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely near Saint Joseph.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Soto to Saint Joseph?
The road trip is about 334.3 miles (538 km) and usually takes 05h 08m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Rocheport is a useful midpoint, sitting about 165.2 miles from De Soto and 169.1 miles from Saint Joseph.
How much longer is the road route than the straight-line distance?
The direct path is about 256.6 miles (412.9 km), while the road route adds roughly 77.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:44 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $44.50 one way or $89.00 round trip. Estimated CO2 is about 104.9 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around De Soto and Slight Chance Showers And Thunderstorms then Showers And Thunderstorms Likely near Saint Joseph.
Stop Ideas Near Rocheport
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Rocheport.
Jefferson City
Sedalia
Hermann
Warrensburg
Flight Path Map
This map shows the direct air route between De Soto and Saint Joseph. Straight-line distance: 256.55 mi (412.88 km).
#1 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
#2 Saint Joseph
The most populous city in Buchanan County, Missouri.
| Population | 74,074 |
| Coordinates | 39.7686100, -94.8466300 |
| Altitude | 270 |
| Country | United States |
End: Walter Welsh Avenue (-94.846632, 39.768853)
Estimated Travel Time
Distance: 538 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 08m |
| 40 mph (64.37 km/h) | 08h 21m |
| 50 mph (80.47 km/h) | 06h 41m |
| 60 mph (96.56 km/h) | 05h 34m |
| 70 mph (112.65 km/h) | 04h 46m |
| 80 mph (129 km/h) | 04h 10m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $44.50 | $89.00 |
| Mid-grade | $4.25 | $50.19 | $100.37 |
| Premium | $4.65 | $54.92 | $109.83 |
| Diesel | $5.30 | $62.59 | $125.17 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.