How far is De Soto, MO from Saint Charles, MO?
Fastest route
The route from DeSoto, Missouri to St. Charles, Missouri is approximately 56.1 miles long and takes about 1 hour to drive. The directions involve taking MO-21 N and I-270 N.
Directions
- Start on Boyd St and head east toward N Main St.
- Turn left to stay on MO-21 N.
- Continue on MO-21 N and then take I-270 N.
- Merge onto MO-94 E/S 1st Capitol Dr in Saint Charles by taking exit 228 from I-70 W.
- Turn right onto Watson St in Lindenwood Township.
Tips & Suggestions
- 🛣️ Follow MO-110 W to MO-21 N in Hillsboro.
- 🚗 Use the left 2 lanes to turn slightly left and then use the right 2 lanes to take the Kansas City/I-70 E exit toward St. Louis.
- 🔄 Keep left at the fork to continue on Exit 20B and merge onto I-70 W.
- 📍 Pass by Valvoline Instant Oil Change (on the right in 23.8 mi).
- 🚙 Use the right 2 lanes to take exit 228 to merge onto MO-94 E/S 1st Capitol Dr.
- 🚧 Continue straight onto S Kingshighway St.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 02m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Suburb city of St.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between De Soto and Saint Charles.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Soto and Saint Charles.
-
1
Start on Easton Street
133 m · 24 sec · Easton Street
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2
At the end of the road, turn left onto North Main Street
1.4 mi · 2 min · North Main Street
-
3
At the end of the road, turn left
1.5 mi · 2 min
-
4
At the end of the road, turn right
124 m · 6 sec
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5
Continue straight
3.8 mi · 5 min
-
6
Turn left
1894 ft · 36 sec
-
7
Continue on MO 21 North: Saint Louis
19.7 mi · 23 min
-
8
Take the exit slight right toward MO 141: Arnold, Fenton
1384 ft · 24 sec
-
9
Turn left
4 mi · 6 min
-
10
Take the exit right toward MO 30 East: Saint Louis
1229 ft · 17 sec
-
11
Merge slight left
2.5 mi · 4 min
-
12
Take the exit left toward I 270 North
2202 ft · 35 sec
-
13
Merge slight left
14.7 mi · 18 min
-
14
Take the exit slight right toward I 70: Kansas City, Saint Louis, Saint Louis Lambert International Airport
1 mi · 1 min
-
15
Keep slight left to continue on I 70 West: Kansas City
645 ft · 11 sec
-
16
Continue on I 70 West: Kansas City
1 km · 57 sec
-
17
Merge slight left
2.7 mi · 3 min
-
18
Take the exit slight right toward I 70 Business: Fifth Street
841 ft · 18 sec
-
19
Keep slight right to continue on I 70 Business: Fifth Street North, Bass Pro Drive, Ameristar Boulevard
71 m · 5 sec
-
20
Turn slight right onto South Fifth Street
1.4 km · 2 min · South Fifth Street
-
21
Turn right onto First Capitol Drive
1079 ft · 42 sec · First Capitol Drive
-
22
Turn left onto South Second Street
1551 ft · 53 sec · South Second Street
-
23
Arrive at your destination
0 m · 1 sec · North Second Street
Car Route Details
A richer read on the saved driving route between De Soto and Saint Charles.
Turn-heavy local drive
The route has frequent decision points for its length, so lane choice and turn timing will matter more than cruising speed.
MO 21 North
Continue on MO 21 North: Saint Louis
19.7 mi · 00h 23m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Sunny leaving De Soto and Mostly Sunny near Saint Charles.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Soto to Saint Charles?
The road trip is about 55.4 miles (89.2 km) and usually takes 01h 02m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Fenton is a useful midpoint, sitting about 27.6 miles from De Soto and 27.9 miles from Saint Charles.
How much longer is the road route than the straight-line distance?
The direct path is about 44.7 miles (71.9 km), while the road route adds roughly 10.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 4:24 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $7.39 one way or $14.78 round trip. Estimated CO2 is about 17.4 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around De Soto and Mostly Sunny near Saint Charles.
Stop Ideas Near Fenton
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Fenton.
Kirkwood
Gateway Transportation Center
Washington
Alton
Flight Path Map
This map shows the direct air route between De Soto and Saint Charles. Straight-line distance: 44.71 mi (71.95 km).
#1 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
#2 Saint Charles
A city in St.
| Population | 71,761 |
| Coordinates | 38.7839400, -90.4812300 |
| Altitude | 147 |
| Country | United States |
End: North Second Street (-90.481269, 38.783952)
Estimated Travel Time
Distance: 89 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 01h 50m |
| 40 mph (64.37 km/h) | 01h 23m |
| 50 mph (80.47 km/h) | 01h 06m |
| 60 mph (96.56 km/h) | 00h 55m |
| 70 mph (112.65 km/h) | 00h 47m |
| 80 mph (129 km/h) | 00h 41m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $7.39 | $14.78 |
| Mid-grade | $4.25 | $8.34 | $16.67 |
| Premium | $4.65 | $9.12 | $18.24 |
| Diesel | $5.30 | $10.40 | $20.79 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.