How far is Key Largo, FL from Tampa, FL?
The driving distance from Key Largo, FL to Tampa, FL is about 324.8 miles (522.7 km), with a travel time of about 05h 03m by car.
- The straight-line flight distance is about 233.5 miles (375.8 km).
- For a round trip, plan for roughly 10h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 03m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Key Largo and Tampa.
Turn-by-Turn Driving Directions
Step-by-step road directions between Key Largo and Tampa.
-
1
Start on Harbor Drive
94 m · 16 sec · Harbor Drive
-
2
Turn right onto Overseas Highway
9.3 mi · 16 min · Overseas Highway
-
3
Continue on Dixie Highway
19.4 mi · 27 min · Dixie Highway
-
4
Take the exit slight right toward Miami, Orlando, Florida's Turnpike North
1785 ft · 38 sec
-
5
Continue on Homestead Extension of Florida's Turnpike
13.2 mi · 16 min · Homestead Extension of Florida's Turnpike
-
6
Keep slight right to continue on Homestead Extension of Florida's Turnpike
3.6 mi · 5 min · Homestead Extension of Florida's Turnpike
-
7
Keep slight left to continue on Homestead Extension of Florida's Turnpike
2.5 mi · 3 min · Homestead Extension of Florida's Turnpike
-
8
Keep slight right to continue on Homestead Extension of Florida's Turnpike
15.5 mi · 18 min · Homestead Extension of Florida's Turnpike
-
9
Take the exit slight right toward US 27: Okeechobee Road
1140 ft · 28 sec
-
10
Keep slight right to continue on US 27: Okeechobee Road
633 ft · 16 sec
-
11
Merge slight left onto Okeechobee Road
17.6 mi · 23 min · Okeechobee Road
-
12
Take the exit slight right toward I 75: Miami, Fort Lauderdale, Naples
1360 ft · 33 sec
-
13
Keep slight left to continue on I 75 North: Naples
1.3 km · 2 min
-
14
Merge slight left onto Alligator Alley
230.3 mi · 4 hr 8 min · Alligator Alley
-
15
Take the exit slight right toward FL 618 Toll West, Selmon Expressway West: Tampa, Port of Tampa
2.4 mi · 3 min
-
16
Continue on Lee Roy Selmon Expressway
7.8 mi · 9 min · Lee Roy Selmon Expressway
-
17
Take the exit slight right toward FL 60: Kennedy Boulevard, Downtown - East
1212 ft · 31 sec
-
18
Turn straight onto East Kennedy Boulevard
1885 ft · 1 min · East Kennedy Boulevard
-
19
Arrive at your destination
0 m · 1 sec · East Kennedy Boulevard
Car Route Details
A richer read on the saved driving route between Key Largo and Tampa.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Alligator Alley
Merge slight left onto Alligator Alley
230 mi · 04h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Key Largo and Mostly Sunny near Tampa.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Key Largo to Tampa?
The road trip is about 324.8 miles (522.7 km) and usually takes 05h 03m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Golden Gate is a useful midpoint, sitting about 162.2 miles from Key Largo and 162.6 miles from Tampa.
How much longer is the road route than the straight-line distance?
The direct path is about 233.5 miles (375.8 km), while the road route adds roughly 91.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:52 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $47.54 one way or $95.07 round trip. Estimated CO2 is about 101.8 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Key Largo and Mostly Sunny near Tampa.
Stop Ideas Near Golden Gate
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Golden Gate.
Fort Myers, Florida
Port Charlotte, Florida
Flight Path Map
This map shows the direct air route between Key Largo and Tampa. Straight-line distance: 233.52 mi (375.81 km).
#1 Key Largo
Census designated place in Florida, United States
| Population | 10,433 |
| Coordinates | 25.0865200, -80.4472800 |
| Altitude | 2 |
| Country | United States |
#2 Tampa
The third most populous city in Florida and the center of the Tampa metropolitan area.
| Population | 407,599 |
| Coordinates | 27.9475200, -82.4584300 |
| Altitude | 1 |
| Country | United States |
End: Kennedy Boulevard (-82.458429, 27.947518)
Estimated Travel Time
Distance: 523 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 49m |
| 40 mph (64.37 km/h) | 08h 07m |
| 50 mph (80.47 km/h) | 06h 29m |
| 60 mph (96.56 km/h) | 05h 24m |
| 70 mph (112.65 km/h) | 04h 38m |
| 80 mph (129 km/h) | 04h 03m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $47.54 | $95.07 |
| Mid-grade | $4.60 | $52.67 | $105.34 |
| Premium | $4.90 | $56.11 | $112.22 |
| Diesel | $4.35 | $49.85 | $99.70 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.