How far is Tampa, FL from Key Largo, FL?
The driving distance from Tampa, FL to Key Largo, FL is about 323.2 miles (520.2 km), with a travel time of about 06h 10m by car.
- The straight-line flight distance is about 233.5 miles (375.8 km).
- For a round trip, plan for roughly 12h 20m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 10m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers
Driving Route Map
The map below follows the saved road route between Tampa and Key Largo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Tampa and Key Largo.
-
1
Start on East Kennedy Boulevard
36 m · 11 sec · East Kennedy Boulevard
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2
Turn left onto North Tampa Street
90 m · 13 sec · North Tampa Street
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3
Turn left onto East Jackson Street
2823 ft · 2 min · East Jackson Street
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4
Keep slight left to continue on East Jackson Street
21 m · 4 sec · East Jackson Street
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5
Turn left onto North Nebraska Avenue
123 m · 10 sec · North Nebraska Avenue
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6
Take the ramp slight right toward FL 618 Toll East: Brandon
853 ft · 21 sec
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7
Merge slight left onto Lee Roy Selmon Expressway
7.8 mi · 9 min · Lee Roy Selmon Expressway
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8
Keep slight right to continue on I 75 South: Naples
2585 ft · 34 sec
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9
Merge slight left
55.8 mi · 1 hr
-
10
Keep slight left
175.7 mi · 3 hr 8 min
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11
Take the exit slight right toward US 27: Miami, South Bay
1118 ft · 21 sec
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12
Keep slight right to continue on US 27 South: Miami
2407 ft · 59 sec
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13
Merge slight left
9.2 mi · 11 min
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14
Keep slight right
8.6 mi · 11 min
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15
Take the exit right toward Florida's Turnpike South: Homestead, Key West
1324 ft · 32 sec
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16
Merge slight left onto Homestead Extension of Florida's Turnpike
34.5 mi · 41 min · Homestead Extension of Florida's Turnpike
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17
Keep slight left
2930 ft · 1 min
-
18
Merge slight left onto Dixie Highway
19.2 mi · 27 min · Dixie Highway
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19
Continue on Overseas Highway
9.3 mi · 16 min · Overseas Highway
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20
Continue on Overseas Highway
138 m · 28 sec · Overseas Highway
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21
Turn right onto Harbor Drive
94 m · 14 sec · Harbor Drive
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22
Arrive at your destination
0 m · 1 sec · Harbor Drive
Car Route Details
A richer read on the saved driving route between Tampa and Key Largo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 75 South
Keep slight left
176 mi · 03h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny leaving Tampa and Slight Chance Rain Showers near Key Largo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Tampa to Key Largo?
The road trip is about 323.2 miles (520.2 km) and usually takes 06h 10m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Golden Gate is a useful midpoint, sitting about 161.8 miles from Tampa and 161.4 miles from Key Largo.
How much longer is the road route than the straight-line distance?
The direct path is about 233.5 miles (375.8 km), while the road route adds roughly 89.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $47.33 one way or $94.66 round trip. Estimated CO2 is about 101.4 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Tampa and Slight Chance Rain Showers near Key Largo.
Stop Ideas Near Golden Gate
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Golden Gate.
Fort Myers, Florida
Port Charlotte, Florida
Flight Path Map
This map shows the direct air route between Tampa and Key Largo. Straight-line distance: 233.52 mi (375.81 km).
#1 Tampa
The third most populous city in Florida and the center of the Tampa metropolitan area.
| Population | 407,599 |
| Coordinates | 27.9475200, -82.4584300 |
| Altitude | 1 |
| Country | United States |
#2 Key Largo
Census designated place in Florida, United States
| Population | 10,433 |
| Coordinates | 25.0865200, -80.4472800 |
| Altitude | 2 |
| Country | United States |
End: Key Largo (-80.44728, 25.08652)
Estimated Travel Time
Distance: 520 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 46m |
| 40 mph (64.37 km/h) | 08h 04m |
| 50 mph (80.47 km/h) | 06h 27m |
| 60 mph (96.56 km/h) | 05h 23m |
| 70 mph (112.65 km/h) | 04h 37m |
| 80 mph (129 km/h) | 04h 01m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $47.33 | $94.66 |
| Mid-grade | $4.60 | $52.44 | $104.88 |
| Premium | $4.90 | $55.86 | $111.73 |
| Diesel | $4.35 | $49.63 | $99.27 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.