How far is Cape Girardeau, MO from Mexico, MO?
The driving distance from Cape Girardeau, MO to Mexico, MO is about 220.8 miles (355.3 km), with a travel time of about 04h 16m by car.
- The straight-line flight distance is about 181.8 miles (292.6 km).
- For a round trip, plan for roughly 08h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 16m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Suburb of St.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms then Showers And Thunderstorms
Isolated Rain Showers
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Mexico.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Mexico.
-
1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
11.5 mi · 14 min
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10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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13
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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15
Merge slight left onto Dwight D Eisenhower Highway
61.6 mi · 1 hr 11 min · Dwight D Eisenhower Highway
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16
Take the exit slight right toward US 54: Auxvasse, Mexico, Fulton
1033 ft · 22 sec
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17
Turn right
13.3 mi · 15 min
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18
Take the exit slight right toward US 54 Business, MO 15, MO 22: Mexico
1135 ft · 34 sec
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19
Turn left
3.8 mi · 6 min
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20
Turn right onto High Street
677 ft · 33 sec · High Street
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21
At the end of the road, turn left onto South Jefferson Street
51 m · 7 sec · South Jefferson Street
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22
Arrive at your destination
0 m · 1 sec · South Jefferson Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Mexico.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms then Showers And Thunderstorms leaving Cape Girardeau and Isolated Rain Showers near Mexico.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Mexico?
The road trip is about 220.8 miles (355.3 km) and usually takes 04h 16m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Kirkwood is a useful midpoint, sitting about 110.4 miles from Cape Girardeau and 110.4 miles from Mexico.
How much longer is the road route than the straight-line distance?
The direct path is about 181.8 miles (292.6 km), while the road route adds roughly 39 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:26 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.38 one way or $58.75 round trip. Estimated CO2 is about 69.2 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms then Showers And Thunderstorms around Cape Girardeau and Isolated Rain Showers near Mexico.
Stop Ideas Near Kirkwood
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kirkwood.
Kirkwood
Gateway Transportation Center
Alton
Washington
Flight Path Map
This map shows the direct air route between Cape Girardeau and Mexico. Straight-line distance: 181.79 mi (292.57 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Mexico
City in and county seat of Audrain County, Missouri
| Population | 11,530 |
| Coordinates | 39.1697600, -91.8829500 |
| Altitude | 244 |
| Country | United States |
End: Mexico (-91.88295, 39.16976)
Estimated Travel Time
Distance: 355 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 21m |
| 40 mph (64.37 km/h) | 05h 31m |
| 50 mph (80.47 km/h) | 04h 24m |
| 60 mph (96.56 km/h) | 03h 40m |
| 70 mph (112.65 km/h) | 03h 09m |
| 80 mph (129 km/h) | 02h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.38 | $58.75 |
| Mid-grade | $4.25 | $33.13 | $66.26 |
| Premium | $4.65 | $36.25 | $72.51 |
| Diesel | $5.30 | $41.32 | $82.64 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 16, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.