How far is Mexico, MO from Cape Girardeau, MO?
The driving distance from Mexico, MO to Cape Girardeau, MO is about 223.8 miles (360.1 km), with a travel time of about 03h 25m by car.
- The straight-line flight distance is about 181.8 miles (292.6 km).
- For a round trip, plan for roughly 06h 51m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 25m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Suburb of St.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Isolated Rain Showers
Chance Showers And Thunderstorms then Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Mexico and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mexico and Cape Girardeau.
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1
Start on South Jefferson Street
51 m · 8 sec · South Jefferson Street
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2
Turn right onto High Street
677 ft · 34 sec · High Street
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3
Turn left onto South Clark Street
3.6 mi · 6 min · South Clark Street
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4
Take the ramp right toward US 54 West: Jefferson City
1180 ft · 32 sec
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5
Merge slight left
13.5 mi · 15 min
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6
Take the exit left toward I 70 East, US 40 East: Saint Louis
1318 ft · 18 sec
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7
Merge slight left onto Dwight D. Eisenhower Highway
61.9 mi · 1 hr 11 min · Dwight D. Eisenhower Highway
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8
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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9
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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10
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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11
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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12
Merge slight left
11.5 mi · 14 min
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13
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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14
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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15
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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16
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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17
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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18
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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19
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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20
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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21
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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22
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Mexico and Cape Girardeau.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Isolated Rain Showers leaving Mexico and Chance Showers And Thunderstorms then Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mexico to Cape Girardeau?
The road trip is about 223.8 miles (360.1 km) and usually takes 03h 25m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Kirkwood is a useful midpoint, sitting about 110.2 miles from Mexico and 113.6 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 181.8 miles (292.6 km), while the road route adds roughly 42 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:08 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.79 one way or $59.58 round trip. Estimated CO2 is about 70.2 kg one way.
What should you check before leaving?
Before you leave, expect Isolated Rain Showers around Mexico and Chance Showers And Thunderstorms then Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Kirkwood
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kirkwood.
Kirkwood
Gateway Transportation Center
Alton
Washington
Flight Path Map
This map shows the direct air route between Mexico and Cape Girardeau. Straight-line distance: 181.79 mi (292.57 km).
#1 Mexico
City in and county seat of Audrain County, Missouri
| Population | 11,530 |
| Coordinates | 39.1697600, -91.8829500 |
| Altitude | 244 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 360 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 27m |
| 40 mph (64.37 km/h) | 05h 35m |
| 50 mph (80.47 km/h) | 04h 28m |
| 60 mph (96.56 km/h) | 03h 43m |
| 70 mph (112.65 km/h) | 03h 11m |
| 80 mph (129 km/h) | 02h 47m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.79 | $59.58 |
| Mid-grade | $4.25 | $33.60 | $67.20 |
| Premium | $4.65 | $36.77 | $73.53 |
| Diesel | $5.30 | $41.90 | $83.80 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 16, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.