How far is Port Saint Lucie, FL from San Antonio, FL?
The driving distance from Port Saint Lucie, FL to San Antonio, FL is about 160.1 miles (257.6 km), with a travel time of about 03h 28m by car.
- The straight-line flight distance is about 137.9 miles (221.9 km).
- For a round trip, plan for roughly 06h 56m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 28m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place in Florida, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and San Antonio.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight right to continue on Orlando, Florida's Turnpike North
1842 ft · 45 sec
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7
Merge slight left onto Florida's Turnpike
49.6 mi · 53 min · Florida's Turnpike
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8
Take the exit slight right toward US 441, FL 60: Yeehaw Junction
1.1 km · 2 min
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9
Keep slight right
75 m · 7 sec
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10
Merge slight left
61.6 mi · 1 hr 19 min
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11
Turn left onto Van Fleet Drive
3253 ft · 1 min · Van Fleet Drive
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12
Turn right onto Broadway Avenue
3184 ft · 1 min · Broadway Avenue
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13
Continue on Bartow Road
11.9 mi · 18 min · Bartow Road
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14
Turn right onto North Florida Avenue
25.5 mi · 36 min · North Florida Avenue
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15
Turn right onto Dade City
1589 ft · 29 sec
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16
Turn left onto Clinton Avenue
3.1 mi · 5 min · Clinton Avenue
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17
Turn right onto Prospect Road
1440 ft · 49 sec · Prospect Road
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18
Turn left onto Old State Road 52
2 mi · 3 min · Old State Road 52
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19
Enter the roundabout and take exit 2 toward College Avenue
34 m · 3 sec · College Avenue
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20
Exit the roundabout onto College Avenue
116 m · 13 sec · College Avenue
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21
At the end of the road, turn right onto Park Street
59 m · 5 sec · Park Street
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22
Continue on Pennsylvania Avenue
923 ft · 26 sec · Pennsylvania Avenue
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23
Arrive at your destination
0 m · 1 sec · Pennsylvania Avenue
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and San Antonio.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
US 441
Merge slight left
61.6 mi · 01h 19m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Port Saint Lucie and Sunny near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to San Antonio?
The road trip is about 160.1 miles (257.6 km) and usually takes 03h 28m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Babson Park is a useful midpoint, sitting about 80 miles from Port Saint Lucie and 80 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 137.9 miles (221.9 km), while the road route adds roughly 22.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 10:04 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $23.44 one way or $46.87 round trip. Estimated CO2 is about 50.2 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Port Saint Lucie and Sunny near San Antonio.
Stop Ideas Near Babson Park
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Babson Park.
Winter Haven
Sebring
Lakeland
Lakeland
Flight Path Map
This map shows the direct air route between Port Saint Lucie and San Antonio. Straight-line distance: 137.88 mi (221.9 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 San Antonio
City in Pasco County, Florida, USA
| Population | 1,506 |
| Coordinates | 28.3361100, -82.2745300 |
| Altitude | 51 |
| Country | United States |
End: San Antonio (-82.27453, 28.33611)
Estimated Travel Time
Distance: 258 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 19m |
| 40 mph (64.37 km/h) | 04h 00m |
| 50 mph (80.47 km/h) | 03h 12m |
| 60 mph (96.56 km/h) | 02h 40m |
| 70 mph (112.65 km/h) | 02h 17m |
| 80 mph (129 km/h) | 01h 59m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $23.44 | $46.87 |
| Mid-grade | $4.60 | $25.97 | $51.93 |
| Premium | $4.90 | $27.66 | $55.32 |
| Diesel | $4.35 | $24.58 | $49.16 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.