How far is Myrtle Grove, FL from Gainesville, FL?
The driving distance from Myrtle Grove, FL to Gainesville, FL is about 347.9 miles (559.9 km), with a travel time of about 05h 19m by car.
- The straight-line flight distance is about 302.7 miles (487.2 km).
- For a round trip, plan for roughly 10h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 19m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Gadsden County, Florida, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Partly Sunny
Driving Route Map
The map below follows the saved road route between Myrtle Grove and Gainesville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Myrtle Grove and Gainesville.
-
1
Start on the route
37 m · 11 sec
-
2
At the end of the road, turn right
16 m · 9 sec
-
3
Turn left onto Lillian Highway
1.6 km · 2 min · Lillian Highway
-
4
Turn left onto North 57th Avenue
2274 ft · 1 min · North 57th Avenue
-
5
At the end of the road, turn right onto West Fairfield Drive
3.8 mi · 7 min · West Fairfield Drive
-
6
Keep slight left to continue on West Fairfield Drive
1.4 km · 2 min · West Fairfield Drive
-
7
Turn right onto North Davis Highway
597 ft · 12 sec · North Davis Highway
-
8
Take the ramp right toward I 110 North
993 ft · 24 sec
-
9
Merge slight left onto Reubin O'Donovan Askew Parkway
3.3 mi · 4 min · Reubin O'Donovan Askew Parkway
-
10
Keep slight right to continue on I 10 East, FL 291: Tallahassee, Davis Highway
1328 ft · 28 sec
-
11
Keep slight left to continue on I 10 East: Tallahassee
1.1 km · 1 min
-
12
Merge slight left
282.9 mi · 5 hr 3 min
-
13
Take the exit slight right toward I-75 South: Tampa
1959 ft · 37 sec
-
14
Merge slight left
47.2 mi · 51 min
-
15
Take the exit slight right toward FL 26: Gainesville, Newberry, Newberry Road
1141 ft · 28 sec
-
16
Turn right onto West Newberry Road
2.4 mi · 5 min · West Newberry Road
-
17
Continue on West University Avenue
3.4 mi · 9 min · West University Avenue
-
18
Turn right onto South Main Street
35 m · 3 sec · South Main Street
-
19
Arrive at your destination
0 m · 1 sec · South Main Street
Car Route Details
A richer read on the saved driving route between Myrtle Grove and Gainesville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 10 East
Merge slight left
283 mi · 05h 03m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving Myrtle Grove and Partly Sunny near Gainesville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Myrtle Grove to Gainesville?
The road trip is about 347.9 miles (559.9 km) and usually takes 05h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Gretna is a useful midpoint, sitting about 173.4 miles from Myrtle Grove and 174.5 miles from Gainesville.
How much longer is the road route than the straight-line distance?
The direct path is about 302.7 miles (487.2 km), while the road route adds roughly 45.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:20 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $50.94 one way or $101.87 round trip. Estimated CO2 is about 109.1 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Myrtle Grove and Gainesville, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Partly Sunny around Myrtle Grove and Partly Sunny near Gainesville.
Flight Path Map
This map shows the direct air route between Myrtle Grove and Gainesville. Straight-line distance: 302.71 mi (487.17 km).
#1 Myrtle Grove
Census-designated place in Escambia County, Florida
| Population | 15,870 |
| Coordinates | 30.4210300, -87.3074700 |
| Altitude | 14 |
| Country | United States |
#2 Gainesville
The third most populous city in Florida.
| Population | 135,004 |
| Coordinates | 29.6516300, -82.3248300 |
| Altitude | 54 |
| Country | United States |
End: South Main Street (-82.32501, 29.65163)
Estimated Travel Time
Distance: 560 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 35m |
| 40 mph (64.37 km/h) | 08h 41m |
| 50 mph (80.47 km/h) | 06h 57m |
| 60 mph (96.56 km/h) | 05h 47m |
| 70 mph (112.65 km/h) | 04h 58m |
| 80 mph (129 km/h) | 04h 20m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $50.94 | $101.87 |
| Mid-grade | $4.60 | $56.44 | $112.88 |
| Premium | $4.90 | $60.12 | $120.25 |
| Diesel | $4.35 | $53.42 | $106.84 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.