How far is Gainesville, FL from Myrtle Grove, FL?
The driving distance from Gainesville, FL to Myrtle Grove, FL is about 346.6 miles (557.8 km), with a travel time of about 06h 26m by car.
- The straight-line flight distance is about 302.7 miles (487.2 km).
- For a round trip, plan for roughly 12h 53m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 26m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Gadsden County, Florida, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Gainesville and Myrtle Grove.
Turn-by-Turn Driving Directions
Step-by-step road directions between Gainesville and Myrtle Grove.
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1
Start on South Main Street
35 m · 11 sec · South Main Street
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2
Turn left onto West University Avenue
3.3 mi · 9 min · West University Avenue
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3
Continue on Newberry Road
2.3 mi · 5 min · Newberry Road
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4
Take the exit slight right toward I 75 North: Lake City
2013 ft · 49 sec
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5
Merge slight left
46.7 mi · 50 min
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6
Take the exit slight right toward I 10: Jacksonville, Tallahassee
820 ft · 16 sec
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7
Keep slight left to continue on I 10 West: Tallahassee
1569 ft · 30 sec
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8
Merge slight right
283.4 mi · 5 hr 4 min
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9
Take the exit slight right toward I 110 South: Pensacola, Pensacola Beach
1.4 km · 1 min
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10
Merge slight left onto Reubin O'Donovan Askew Parkway
2.7 mi · 3 min · Reubin O'Donovan Askew Parkway
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11
Take the exit slight right toward FL 295: Fairfield Drive
1615 ft · 39 sec
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12
Keep slight right to continue on FL 295 South
610 ft · 17 sec
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13
Turn straight onto East Fairfield Drive
2.9 mi · 6 min · East Fairfield Drive
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14
Continue on Fairfield Drive
1.6 mi · 3 min · Fairfield Drive
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15
Turn left onto North 57th Avenue
2274 ft · 1 min · North 57th Avenue
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16
Turn right onto Lillian Highway
1 mi · 2 min · Lillian Highway
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17
Turn right
13 m · 5 sec
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18
Turn right
25 m · 6 sec
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19
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Gainesville and Myrtle Grove.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 10 West
Merge slight right
283 mi · 05h 04m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny leaving Gainesville and Sunny near Myrtle Grove.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Gainesville to Myrtle Grove?
The road trip is about 346.6 miles (557.8 km) and usually takes 06h 26m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Gretna is a useful midpoint, sitting about 173.2 miles from Gainesville and 173.5 miles from Myrtle Grove.
How much longer is the road route than the straight-line distance?
The direct path is about 302.7 miles (487.2 km), while the road route adds roughly 43.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $50.73 one way or $101.46 round trip. Estimated CO2 is about 108.7 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Gainesville and Myrtle Grove, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Gainesville and Sunny near Myrtle Grove.
Flight Path Map
This map shows the direct air route between Gainesville and Myrtle Grove. Straight-line distance: 302.71 mi (487.17 km).
#1 Gainesville
The third most populous city in Florida.
| Population | 135,004 |
| Coordinates | 29.6516300, -82.3248300 |
| Altitude | 54 |
| Country | United States |
#2 Myrtle Grove
Census-designated place in Escambia County, Florida
| Population | 15,870 |
| Coordinates | 30.4210300, -87.3074700 |
| Altitude | 14 |
| Country | United States |
End: Myrtle Grove (-87.30747, 30.42103)
Estimated Travel Time
Distance: 558 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 32m |
| 40 mph (64.37 km/h) | 08h 39m |
| 50 mph (80.47 km/h) | 06h 55m |
| 60 mph (96.56 km/h) | 05h 46m |
| 70 mph (112.65 km/h) | 04h 57m |
| 80 mph (129 km/h) | 04h 19m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $50.73 | $101.46 |
| Mid-grade | $4.60 | $56.21 | $112.42 |
| Premium | $4.90 | $59.88 | $119.76 |
| Diesel | $4.35 | $53.20 | $106.40 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.