How far is Mesquite, TX from Amarillo, TX?
The driving distance from Mesquite, TX to Amarillo, TX is about 377.6 miles (607.7 km), with a travel time of about 05h 50m by car.
- The straight-line flight distance is about 344.3 miles (554.1 km).
- For a round trip, plan for roughly 11h 41m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 50m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Areas Of Fog
Driving Route Map
The map below follows the saved road route between Mesquite and Amarillo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mesquite and Amarillo.
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1
Start on South Galloway Avenue
1 m · 7 sec · South Galloway Avenue
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2
Turn left onto West Main Street
2020 ft · 57 sec · West Main Street
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3
Continue on Scyene Road
1.5 km · 2 min · Scyene Road
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4
Take the ramp slight right toward I 635 North
1817 ft · 44 sec
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5
Merge slight left onto Lyndon B Johnson Freeway
13.5 mi · 14 min · Lyndon B Johnson Freeway
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6
Continue on Lyndon B. Johnson Freeway
4.1 mi · 4 min · Lyndon B. Johnson Freeway
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7
Continue on Lyndon B Johnson Freeway
4.6 mi · 5 min · Lyndon B Johnson Freeway
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8
Take the exit slight right toward I 35E North: Denton
1696 ft · 42 sec
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9
Merge slight left onto North Stemmons Freeway
28.2 mi · 30 min · North Stemmons Freeway
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10
Continue straight
782 ft · 10 sec
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11
Take the exit slight right toward US 380: University Drive
672 ft · 16 sec
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12
Turn straight onto North Interstate 35
2258 ft · 47 sec · North Interstate 35
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13
Turn left onto West University Drive
3.4 mi · 5 min · West University Drive
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14
Continue on US Highway 380 West
21.5 mi · 25 min · US Highway 380 West
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15
Take the exit slight right
1443 ft · 40 sec
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16
Merge slight left onto North US Highway 287
72.5 mi · 1 hr 15 min · North US Highway 287
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17
Continue on Lloyd Ruby Overpass
1.3 km · 59 sec · Lloyd Ruby Overpass
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18
Continue on Central Freeway
2.4 mi · 3 min · Central Freeway
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19
Keep slight left to continue on Northwest Freeway
5.3 mi · 6 min · Northwest Freeway
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20
Continue on US Highway 287 East
40.5 mi · 42 min · US Highway 287 East
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21
Continue on Martin Luther King Jr Memorial Highway
4.1 mi · 4 min · Martin Luther King Jr Memorial Highway
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22
Continue on US Highway 287 West
25.7 mi · 26 min · US Highway 287 West
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23
Continue on East 11th Street
28.7 mi · 33 min · East 11th Street
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24
Continue on Avenue F Northeast
2.8 mi · 3 min · Avenue F Northeast
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25
Continue on US Highway 287
13.8 mi · 15 min · US Highway 287
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26
Continue on Burnett Street
1.1 km · 1 min · Burnett Street
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27
Continue on US Highway 287
13.6 mi · 14 min · US Highway 287
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28
Turn straight onto Boykin Drive
26.2 mi · 28 min · Boykin Drive
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29
Continue on East 2nd Street
1.6 mi · 2 min · East 2nd Street
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30
Continue on US Highway 287
28.4 mi · 29 min · US Highway 287
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31
Continue on East 1st Street
1.1 mi · 2 min · East 1st Street
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32
Continue on US Highway 287
19.6 mi · 20 min · US Highway 287
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33
Keep slight right to continue on East Interstate Drive
100 m · 8 sec · East Interstate Drive
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34
Keep slight right to continue on Southeast 3rd Avenue
2.6 mi · 4 min · Southeast 3rd Avenue
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35
Take the ramp left
946 ft · 26 sec
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36
Merge slight left onto North Lakeside Drive
1.3 mi · 1 min · North Lakeside Drive
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37
Take the exit slight right toward US 60, I 40 Business: Amarillo Boulevard
1620 ft · 46 sec
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38
Turn left onto East Amarillo Boulevard
4.4 mi · 5 min · East Amarillo Boulevard
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39
Continue straight
1.4 km · 1 min
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40
Continue on East Amarillo Boulevard
534 ft · 17 sec · East Amarillo Boulevard
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41
Arrive at your destination
0 m · 1 sec · East Amarillo Boulevard
Car Route Details
A richer read on the saved driving route between Mesquite and Amarillo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
North US Highway 287
Merge slight left onto North US Highway 287
72.5 mi · 01h 15m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Mesquite and Areas Of Fog near Amarillo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mesquite to Amarillo?
The road trip is about 377.6 miles (607.7 km) and usually takes 05h 50m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Electra is a useful midpoint, sitting about 187.7 miles from Mesquite and 189.9 miles from Amarillo.
How much longer is the road route than the straight-line distance?
The direct path is about 344.3 miles (554.1 km), while the road route adds roughly 33.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:18 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $51.14 one way or $102.27 round trip. Estimated CO2 is about 118.4 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Mesquite and Areas Of Fog near Amarillo.
Flight Path Map
This map shows the direct air route between Mesquite and Amarillo. Straight-line distance: 344.32 mi (554.13 km).
#1 Mesquite
The ninth most populous city in Texas.
| Population | 138,916 |
| Coordinates | 32.7668000, -96.5991600 |
| Altitude | 151 |
| Country | United States |
#2 Amarillo
The second most populous city in Texas Panhandle.
| Population | 199,654 |
| Coordinates | 35.2220000, -101.8313000 |
| Altitude | 1118 |
| Country | United States |
End: East Amarillo Boulevard (-101.8313, 35.221963)
Estimated Travel Time
Distance: 608 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 34m |
| 40 mph (64.37 km/h) | 09h 26m |
| 50 mph (80.47 km/h) | 07h 33m |
| 60 mph (96.56 km/h) | 06h 17m |
| 70 mph (112.65 km/h) | 05h 23m |
| 80 mph (129 km/h) | 04h 42m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.84 | $51.14 | $102.27 |
| Mid-grade | $4.35 | $57.90 | $115.80 |
| Premium | $4.72 | $62.91 | $125.82 |
| Diesel | $5.78 | $76.94 | $153.87 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Oct 15, 2026