How far is Mesquite, TX from San Antonio, TX?
The driving distance from Mesquite, TX to San Antonio, TX is about 301.2 miles (484.7 km), with a travel time of about 04h 21m by car.
- The straight-line flight distance is about 256.7 miles (413.1 km).
- For a round trip, plan for roughly 08h 43m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 21m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Texas, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy then Chance Showers And Thunderstorms
Mostly Cloudy
Driving Route Map
The map below follows the saved road route between Mesquite and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mesquite and San Antonio.
-
1
Start on South Galloway Avenue
1 m · 7 sec · South Galloway Avenue
-
2
Turn left onto West Main Street
2020 ft · 57 sec · West Main Street
-
3
Continue on Scyene Road
1 mi · 2 min · Scyene Road
-
4
Turn left onto Rodeo Center Boulevard
697 ft · 26 sec · Rodeo Center Boulevard
-
5
Turn slight left onto I 635 South
1339 ft · 33 sec
-
6
Merge slight left onto Lyndon B Johnson Freeway
16.7 mi · 18 min · Lyndon B Johnson Freeway
-
7
Take the exit slight right toward I 35E South: Waco
1.6 km · 2 min
-
8
Merge slight left onto South R L Thornton Freeway
80.3 mi · 1 hr 22 min · South R L Thornton Freeway
-
9
Continue on North Jack Kultgen Expressway
6.6 mi · 8 min · North Jack Kultgen Expressway
-
10
Continue on Purple Heart Trail
37.9 mi · 39 min · Purple Heart Trail
-
11
Keep slight left
55.8 mi · 59 min
-
12
Keep slight left to continue on Purple Heart Trail
49.8 mi · 55 min · Purple Heart Trail
-
13
Continue on Interstate Highway 35
1.7 mi · 2 min · Interstate Highway 35
-
14
Continue on Purple Heart Trail
11.9 mi · 13 min · Purple Heart Trail
-
15
Continue on North Pan Am Expressway
10 mi · 12 min · North Pan Am Expressway
-
16
Keep slight left to continue on North Pan Am Expressway
6.4 mi · 8 min · North Pan Am Expressway
-
17
Keep slight left to continue on North Pan Am Expressway
2907 ft · 41 sec · North Pan Am Expressway
-
18
Take the exit slight right toward Lexington Avenue, Main Avenue, San Pedro Avenue
684 ft · 17 sec
-
19
Turn straight onto East Elmira Street
526 ft · 17 sec · East Elmira Street
-
20
Turn left onto North Main Avenue
830 ft · 19 sec · North Main Avenue
-
21
Enter the roundabout and take exit 2 toward Navarro Street
49 m · 3 sec · Navarro Street
-
22
Exit the roundabout onto Navarro Street
34 m · 2 sec · Navarro Street
-
23
Keep slight right to continue on North Main Avenue
2181 ft · 52 sec · North Main Avenue
-
24
Turn right onto West Travis Street
68 m · 11 sec · West Travis Street
-
25
Turn left onto North Flores Street
807 ft · 20 sec · North Flores Street
-
26
Continue on Military Plaza
119 m · 16 sec · Military Plaza
-
27
Turn left onto Dolorosa Street
100 m · 8 sec · Dolorosa Street
-
28
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Mesquite and San Antonio.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
South R L Thornton Freeway
Merge slight left onto South R L Thornton Freeway
80.3 mi · 01h 22m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy then Chance Showers And Thunderstorms leaving Mesquite and Mostly Cloudy near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mesquite to San Antonio?
The road trip is about 301.2 miles (484.7 km) and usually takes 04h 21m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Belton is a useful midpoint, sitting about 141.1 miles from Mesquite and 160.1 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 256.7 miles (413.1 km), while the road route adds roughly 44.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:16 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $40.17 one way or $80.34 round trip. Estimated CO2 is about 94.5 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy then Chance Showers And Thunderstorms around Mesquite and Mostly Cloudy near San Antonio.
Stop Ideas Near Belton
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Belton.
Temple
Killeen, Texas
Fort Hood, Texas
McGregor
Flight Path Map
This map shows the direct air route between Mesquite and San Antonio. Straight-line distance: 256.7 mi (413.12 km).
#1 Mesquite
The ninth most populous city in Texas.
| Population | 138,916 |
| Coordinates | 32.7668000, -96.5991600 |
| Altitude | 151 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 485 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 02m |
| 40 mph (64.37 km/h) | 07h 31m |
| 50 mph (80.47 km/h) | 06h 01m |
| 60 mph (96.56 km/h) | 05h 01m |
| 70 mph (112.65 km/h) | 04h 18m |
| 80 mph (129 km/h) | 03h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $40.17 | $80.34 |
| Mid-grade | $4.25 | $45.20 | $90.40 |
| Premium | $4.59 | $48.80 | $97.60 |
| Diesel | $3.99 | $42.45 | $84.89 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.