How far is Key Biscayne, FL from Gainesville, FL?
The driving distance from Key Biscayne, FL to Gainesville, FL is about 343.2 miles (552.3 km), with a travel time of about 05h 22m by car.
- The straight-line flight distance is about 303.8 miles (488.9 km).
- For a round trip, plan for roughly 10h 44m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 22m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Indian River County, Florida, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Key Biscayne and Gainesville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Key Biscayne and Gainesville.
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1
Start on Crandon Boulevard
2829 ft · 1 min · Crandon Boulevard
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2
Continue on Rickenbacker Causeway
5.6 mi · 10 min · Rickenbacker Causeway
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3
Take the ramp straight toward US 1 South, I 95 North: Coral Gables, Downtown, Airport
3007 ft · 1 min
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4
Merge slight left
3.6 mi · 5 min
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5
Keep slight right
7.8 mi · 10 min
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6
Take the exit slight left toward SR 826 West: Florida's Turnpike Toll
1.3 km · 2 min
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7
Keep slight left to continue on Florida's Turnpike
2242 ft · 55 sec
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8
Merge slight right onto Florida's Turnpike
263.9 mi · 4 hr 47 min · Florida's Turnpike
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9
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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10
Merge slight left
46.1 mi · 49 min
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11
Take the exit slight right toward CR 234: Micanopy
1213 ft · 32 sec
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12
Turn right onto Southeast County Road 234
1.3 mi · 2 min · Southeast County Road 234
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13
Turn left
128 m · 15 sec
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14
Turn straight
8 mi · 10 min
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15
Turn right onto Southwest Williston Road
2889 ft · 1 min · Southwest Williston Road
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16
Turn left onto South Main Street
1.6 mi · 3 min · South Main Street
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17
Enter the roundabout and take exit 2 toward South Main Street
28 m · 2 sec · South Main Street
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18
Exit the roundabout onto South Main Street
1317 ft · 32 sec · South Main Street
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19
Enter the roundabout and take exit 2 toward South Main Street
54 m · 4 sec · South Main Street
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20
Exit the roundabout onto South Main Street
2512 ft · 1 min · South Main Street
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21
Arrive at your destination
0 m · 1 sec · South Main Street
Car Route Details
A richer read on the saved driving route between Key Biscayne and Gainesville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Florida's Turnpike
Merge slight right onto Florida's Turnpike
264 mi · 04h 47m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy leaving Key Biscayne and Mostly Sunny near Gainesville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Key Biscayne to Gainesville?
The road trip is about 343.2 miles (552.3 km) and usually takes 05h 22m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Fellsmere is a useful midpoint, sitting about 171.4 miles from Key Biscayne and 171.8 miles from Gainesville.
How much longer is the road route than the straight-line distance?
The direct path is about 303.8 miles (488.9 km), while the road route adds roughly 39.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:16 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $50.23 one way or $100.46 round trip. Estimated CO2 is about 107.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy around Key Biscayne and Mostly Sunny near Gainesville.
Stop Ideas Near Fellsmere
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Fellsmere.
Okeechobee
Sebring
Kissimmee
Orlando Health/Amtrak
Flight Path Map
This map shows the direct air route between Key Biscayne and Gainesville. Straight-line distance: 303.76 mi (488.86 km).
#1 Key Biscayne
Village in Miami-Dade County, Florida
| Population | 12,730 |
| Coordinates | 25.6937100, -80.1628200 |
| Altitude | 1 |
| Country | United States |
#2 Gainesville
The third most populous city in Florida.
| Population | 135,004 |
| Coordinates | 29.6516300, -82.3248300 |
| Altitude | 54 |
| Country | United States |
End: South Main Street (-82.32501, 29.65163)
Estimated Travel Time
Distance: 552 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 26m |
| 40 mph (64.37 km/h) | 08h 34m |
| 50 mph (80.47 km/h) | 06h 51m |
| 60 mph (96.56 km/h) | 05h 43m |
| 70 mph (112.65 km/h) | 04h 54m |
| 80 mph (129 km/h) | 04h 16m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $50.23 | $100.46 |
| Mid-grade | $4.60 | $55.66 | $111.32 |
| Premium | $4.90 | $59.29 | $118.58 |
| Diesel | $4.35 | $52.68 | $105.36 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.