How far is Gladstone, MO from O'Fallon, MO?
The driving distance from Gladstone, MO to O'Fallon, MO is about 224.1 miles (360.7 km), with a travel time of about 03h 24m by car.
- The straight-line flight distance is about 208.7 miles (335.9 km).
- For a round trip, plan for roughly 06h 49m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Cooper County, Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Gladstone and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between Gladstone and O'Fallon.
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1
Start on North Garfield Avenue
126 m · 21 sec · North Garfield Avenue
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2
Turn right onto Northeast 61st Street
1843 ft · 1 min · Northeast 61st Street
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3
Turn right onto North Antioch Road
1.2 km · 2 min · North Antioch Road
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4
Turn left onto Northeast Chouteau Trafficway
1.7 mi · 3 min · Northeast Chouteau Trafficway
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5
Continue on Northeast Chouteau Parkway
1.6 mi · 3 min · Northeast Chouteau Parkway
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6
Continue on North Chouteau Trafficway
1.7 mi · 3 min · North Chouteau Trafficway
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7
Turn left onto East Front Street
1.2 mi · 2 min · East Front Street
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8
Take the ramp slight right toward I 435 South: Grandview
1353 ft · 33 sec
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9
Merge slight left onto Lamar Hunt Memorial Highway
4.4 mi · 5 min · Lamar Hunt Memorial Highway
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10
Keep slight right to continue on I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
1500 ft · 23 sec
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11
Keep slight left to continue on I 70 East: Saint Louis
1.2 mi · 2 min
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12
Keep slight left to continue on I 70 East: Saint Louis
143 m · 12 sec
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13
Merge slight left onto George Brett Super Highway
2213 ft · 29 sec · George Brett Super Highway
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14
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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15
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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16
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
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17
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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18
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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19
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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21
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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22
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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23
Continue on Dwight D. Eisenhower Highway
88.2 mi · 1 hr 44 min · Dwight D. Eisenhower Highway
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24
Take the exit slight right toward MO K: O'Fallon
1765 ft · 43 sec
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25
Turn straight onto Drennen Parkway
46 m · 3 sec · Drennen Parkway
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26
Keep slight right to continue on Drennen Parkway
51 m · 6 sec · Drennen Parkway
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27
Turn slight left onto MO K: O'Fallon
19 m · 3 sec
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28
Continue on South Main Street
3115 ft · 2 min · South Main Street
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29
Turn right
8 m · 2 sec
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30
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Gladstone and O'Fallon.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
88.2 mi · 01h 44m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Gladstone and Showers And Thunderstorms near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Gladstone to O'Fallon?
The road trip is about 224.1 miles (360.7 km) and usually takes 03h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Boonville is a useful midpoint, sitting about 111.2 miles from Gladstone and 113 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 208.7 miles (335.9 km), while the road route adds roughly 15.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:10 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.83 one way or $59.66 round trip. Estimated CO2 is about 70.3 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Gladstone and Showers And Thunderstorms near O'Fallon.
Stop Ideas Near Boonville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Boonville.
Sedalia
Jefferson City
Warrensburg
Hermann
Flight Path Map
This map shows the direct air route between Gladstone and O'Fallon. Straight-line distance: 208.72 mi (335.91 km).
#1 Gladstone
City in Missouri, USA
| Population | 27,677 |
| Coordinates | 39.2038900, -94.5546800 |
| Altitude | 287 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 361 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 28m |
| 40 mph (64.37 km/h) | 05h 36m |
| 50 mph (80.47 km/h) | 04h 28m |
| 60 mph (96.56 km/h) | 03h 44m |
| 70 mph (112.65 km/h) | 03h 12m |
| 80 mph (129 km/h) | 02h 47m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.83 | $59.66 |
| Mid-grade | $4.25 | $33.64 | $67.28 |
| Premium | $4.65 | $36.81 | $73.63 |
| Diesel | $5.30 | $41.95 | $83.91 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.