How far is O'Fallon, MO from Gladstone, MO?
The driving distance from O'Fallon, MO to Gladstone, MO is about 222.5 miles (358 km), with a travel time of about 04h 20m by car.
- The straight-line flight distance is about 208.7 miles (335.9 km).
- For a round trip, plan for roughly 08h 41m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 20m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Cooper County, Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between O'Fallon and Gladstone.
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon and Gladstone.
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1
Start on the route
8 m · 7 sec
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2
Turn left onto South Main Street
3116 ft · 2 min · South Main Street
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3
Turn left onto I 70 East
10 m · 6 sec
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4
Turn sharp left onto South Main Street
87 m · 11 sec · South Main Street
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5
Turn left onto West Terra Lane
576 ft · 12 sec · West Terra Lane
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6
Take the ramp straight toward I 70 West
146 m · 7 sec
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7
Merge slight left
200.7 mi · 3 hr 46 min
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8
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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9
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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10
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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11
Continue on George Brett Super Highway
1.4 km · 58 sec · George Brett Super Highway
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12
Take the exit slight right toward I 435 North, US 24 East: Des Moines
1.1 mi · 2 min
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13
Merge slight left onto Lamar Hunt Memorial Highway
4.1 mi · 5 min · Lamar Hunt Memorial Highway
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14
Take the exit slight right toward East Front Street
746 ft · 18 sec
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15
Turn left onto East Front Street, Riverfront Park Access
54 m · 5 sec
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16
Continue on East Front Street
1.3 mi · 3 min · East Front Street
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17
Turn right onto North Chouteau Trafficway
1.6 mi · 3 min · North Chouteau Trafficway
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18
Continue on Northeast Chouteau Parkway
1.7 mi · 3 min · Northeast Chouteau Parkway
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19
Continue on Northeast Chouteau Trafficway
1.6 mi · 3 min · Northeast Chouteau Trafficway
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20
Turn right onto North Antioch Road
3141 ft · 1 min · North Antioch Road
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21
Turn left onto Northeast 60th Street
1475 ft · 1 min · Northeast 60th Street
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22
At the end of the road, turn right onto North Howard Avenue
105 m · 20 sec · North Howard Avenue
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23
Turn left onto Northeast 60th Terrace
114 m · 22 sec · Northeast 60th Terrace
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24
Turn sharp right onto North Garfield Avenue
41 m · 6 sec · North Garfield Avenue
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25
Arrive at your destination
0 m · 1 sec · North Garfield Avenue
Car Route Details
A richer read on the saved driving route between O'Fallon and Gladstone.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 70 West
Merge slight left
201 mi · 03h 46m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms leaving O'Fallon and Chance Showers And Thunderstorms near Gladstone.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from O'Fallon to Gladstone?
The road trip is about 222.5 miles (358 km) and usually takes 04h 20m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Boonville is a useful midpoint, sitting about 111 miles from O'Fallon and 111.4 miles from Gladstone.
How much longer is the road route than the straight-line distance?
The direct path is about 208.7 miles (335.9 km), while the road route adds roughly 13.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:18 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $29.60 one way or $59.20 round trip. Estimated CO2 is about 69.8 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around O'Fallon and Chance Showers And Thunderstorms near Gladstone.
Stop Ideas Near Boonville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Boonville.
Sedalia
Jefferson City
Warrensburg
Hermann
Flight Path Map
This map shows the direct air route between O'Fallon and Gladstone. Straight-line distance: 208.72 mi (335.91 km).
#1 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
#2 Gladstone
City in Missouri, USA
| Population | 27,677 |
| Coordinates | 39.2038900, -94.5546800 |
| Altitude | 287 |
| Country | United States |
End: Gladstone (-94.55468, 39.20389)
Estimated Travel Time
Distance: 358 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 24m |
| 40 mph (64.37 km/h) | 05h 33m |
| 50 mph (80.47 km/h) | 04h 26m |
| 60 mph (96.56 km/h) | 03h 42m |
| 70 mph (112.65 km/h) | 03h 10m |
| 80 mph (129 km/h) | 02h 46m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $29.60 | $59.20 |
| Mid-grade | $4.25 | $33.39 | $66.77 |
| Premium | $4.65 | $36.53 | $73.07 |
| Diesel | $5.30 | $41.64 | $83.27 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.