How far is Chillicothe, MO from Cape Girardeau, MO?
The driving distance from Chillicothe, MO to Cape Girardeau, MO is about 337.2 miles (542.6 km), with a travel time of about 05h 24m by car.
- The straight-line flight distance is about 277.6 miles (446.8 km).
- For a round trip, plan for roughly 10h 48m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Lincoln County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Chillicothe and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Chillicothe and Cape Girardeau.
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1
Start on Locust Street
16 m · 4 sec · Locust Street
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2
Turn right onto West Calhoun Street
98 m · 18 sec · West Calhoun Street
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3
Turn left onto North Washington Street
1.6 mi · 4 min · North Washington Street
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4
Take the ramp left toward US 36 East, MO 110 East: Brookfield
975 ft · 13 sec
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5
Merge slight left onto Chicago-Kansas City Expressway
111.4 mi · 2 hr 9 min · Chicago-Kansas City Expressway
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6
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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7
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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8
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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9
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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10
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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11
Take the ramp right
37 m · 3 sec
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12
Merge slight left onto Avenue of the Saints
98.7 mi · 1 hr 58 min · Avenue of the Saints
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13
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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14
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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15
Merge slight left
11.5 mi · 14 min
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16
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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17
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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18
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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19
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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20
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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21
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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22
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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23
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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24
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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25
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Chillicothe and Cape Girardeau.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Chicago-Kansas City Expressway
Merge slight left onto Chicago-Kansas City Expressway
111 mi · 02h 09m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely leaving Chillicothe and Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Chillicothe to Cape Girardeau?
The road trip is about 337.2 miles (542.6 km) and usually takes 05h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Whiteside is a useful midpoint, sitting about 168 miles from Chillicothe and 169.3 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 277.6 miles (446.8 km), while the road route adds roughly 59.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:12 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $44.87 one way or $89.75 round trip. Estimated CO2 is about 105.8 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely around Chillicothe and Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Whiteside
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Whiteside.
Hermann
Washington
Alton
Kirkwood
Flight Path Map
This map shows the direct air route between Chillicothe and Cape Girardeau. Straight-line distance: 277.63 mi (446.8 km).
#1 Chillicothe
City in Missouri
| Population | 8,915 |
| Coordinates | 39.7952900, -93.5524400 |
| Altitude | 243 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 543 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 14m |
| 40 mph (64.37 km/h) | 08h 25m |
| 50 mph (80.47 km/h) | 06h 44m |
| 60 mph (96.56 km/h) | 05h 37m |
| 70 mph (112.65 km/h) | 04h 49m |
| 80 mph (129 km/h) | 04h 12m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $44.87 | $89.75 |
| Mid-grade | $4.25 | $50.61 | $101.22 |
| Premium | $4.65 | $55.38 | $110.77 |
| Diesel | $5.30 | $63.12 | $126.24 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.