How far is Cape Girardeau, MO from Chillicothe, MO?
The driving distance from Cape Girardeau, MO to Chillicothe, MO is about 336.3 miles (541.3 km), with a travel time of about 06h 34m by car.
- The straight-line flight distance is about 277.6 miles (446.8 km).
- For a round trip, plan for roughly 13h 09m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 34m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Lincoln County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Chillicothe.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Chillicothe.
-
1
Start on Broadway Street
2 mi · 4 min · Broadway Street
-
2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
-
3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
-
4
Merge slight left
95.1 mi · 1 hr 42 min
-
5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
-
6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
-
7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
-
8
Continue on I 270 West
1.2 km · 1 min
-
9
Merge slight left
11.5 mi · 14 min
-
10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
-
11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
-
12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
-
13
Merge slight left onto Avenue of the Saints
98.8 mi · 1 hr 58 min · Avenue of the Saints
-
14
Take the exit slight left
76 m · 15 sec
-
15
Turn left onto Paris Gravel Road
2645 ft · 1 min · Paris Gravel Road
-
16
Keep slight right to continue on County Road 422
85 m · 9 sec · County Road 422
-
17
Turn right onto Veterans Road
2.2 mi · 4 min · Veterans Road
-
18
Take the ramp left toward US 36 West, MO 110 West: Monroe City
1226 ft · 16 sec
-
19
Merge slight left onto V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
-
20
Continue on Chicago-Kansas City Expressway
111.4 mi · 2 hr 9 min · Chicago-Kansas City Expressway
-
21
Take the exit slight right toward US 65, US 36 Business: Chillicothe, Carrollton
975 ft · 28 sec
-
22
Turn right onto South Washington Street
1.4 mi · 3 min · South Washington Street
-
23
Turn right onto Jackson Street
98 m · 15 sec · Jackson Street
-
24
Turn left onto Locust Street
687 ft · 30 sec · Locust Street
-
25
Arrive at your destination
0 m · 1 sec · Locust Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Chillicothe.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Chicago-Kansas City Expressway
Continue on Chicago-Kansas City Expressway
111 mi · 02h 09m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Showers And Thunderstorms leaving Cape Girardeau and Showers And Thunderstorms Likely near Chillicothe.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Chillicothe?
The road trip is about 336.3 miles (541.3 km) and usually takes 06h 34m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Whiteside is a useful midpoint, sitting about 168.1 miles from Cape Girardeau and 168.3 miles from Chillicothe.
How much longer is the road route than the straight-line distance?
The direct path is about 277.6 miles (446.8 km), while the road route adds roughly 58.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $44.76 one way or $89.52 round trip. Estimated CO2 is about 105.5 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Cape Girardeau and Showers And Thunderstorms Likely near Chillicothe.
Stop Ideas Near Whiteside
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Whiteside.
Hermann
Washington
Alton
Kirkwood
Flight Path Map
This map shows the direct air route between Cape Girardeau and Chillicothe. Straight-line distance: 277.63 mi (446.8 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Chillicothe
City in Missouri
| Population | 8,915 |
| Coordinates | 39.7952900, -93.5524400 |
| Altitude | 243 |
| Country | United States |
End: Chillicothe (-93.55244, 39.79529)
Estimated Travel Time
Distance: 541 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 12m |
| 40 mph (64.37 km/h) | 08h 24m |
| 50 mph (80.47 km/h) | 06h 43m |
| 60 mph (96.56 km/h) | 05h 36m |
| 70 mph (112.65 km/h) | 04h 48m |
| 80 mph (129 km/h) | 04h 11m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $44.76 | $89.52 |
| Mid-grade | $4.25 | $50.48 | $100.97 |
| Premium | $4.65 | $55.24 | $110.49 |
| Diesel | $5.30 | $62.96 | $125.92 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.