How far is Chillicothe, MO from O'Fallon, MO?
The driving distance from Chillicothe, MO to O'Fallon, MO is about 201.3 miles (323.9 km), with a travel time of about 03h 17m by car.
- The straight-line flight distance is about 167 miles (268.7 km).
- For a round trip, plan for roughly 06h 35m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 17m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Monroe County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Slight Chance Showers And Thunderstorms
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Chillicothe and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between Chillicothe and O'Fallon.
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1
Start on Locust Street
16 m · 4 sec · Locust Street
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2
Turn right onto West Calhoun Street
98 m · 18 sec · West Calhoun Street
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3
Turn left onto North Washington Street
1.6 mi · 4 min · North Washington Street
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4
Take the ramp left toward US 36 East, MO 110 East: Brookfield
975 ft · 13 sec
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5
Merge slight left onto Chicago-Kansas City Expressway
111.4 mi · 2 hr 9 min · Chicago-Kansas City Expressway
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6
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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7
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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8
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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9
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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10
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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11
Take the ramp right
37 m · 3 sec
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12
Merge slight left onto Avenue of the Saints
73.7 mi · 1 hr 27 min · Avenue of the Saints
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13
Take the exit slight left toward I 70 East: Saint Louis
2705 ft · 51 sec
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14
Merge slight left onto Dwight D Eisenhower Highway
6.4 mi · 8 min · Dwight D Eisenhower Highway
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15
Take the exit slight right toward MO K: O'Fallon
1765 ft · 43 sec
-
16
Turn straight onto Drennen Parkway
46 m · 3 sec · Drennen Parkway
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17
Keep slight right to continue on Drennen Parkway
51 m · 6 sec · Drennen Parkway
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18
Turn slight left onto MO K: O'Fallon
19 m · 3 sec
-
19
Continue on South Main Street
3115 ft · 2 min · South Main Street
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20
Turn right
8 m · 2 sec
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21
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Chillicothe and O'Fallon.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Chicago-Kansas City Expressway
Merge slight left onto Chicago-Kansas City Expressway
111 mi · 02h 09m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny then Slight Chance Showers And Thunderstorms leaving Chillicothe and Mostly Sunny near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Chillicothe to O'Fallon?
The road trip is about 201.3 miles (323.9 km) and usually takes 03h 17m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Monroe City is a useful midpoint, sitting about 101.7 miles from Chillicothe and 99.6 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 167 miles (268.7 km), while the road route adds roughly 34.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:24 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $26.77 one way or $53.55 round trip. Estimated CO2 is about 63.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Slight Chance Showers And Thunderstorms around Chillicothe and Mostly Sunny near O'Fallon.
Stop Ideas Near Monroe City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Monroe City.
Quincy
La Plata
Hermann
Fort Madison station
Flight Path Map
This map shows the direct air route between Chillicothe and O'Fallon. Straight-line distance: 166.99 mi (268.74 km).
#1 Chillicothe
City in Missouri
| Population | 8,915 |
| Coordinates | 39.7952900, -93.5524400 |
| Altitude | 243 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 324 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 42m |
| 40 mph (64.37 km/h) | 05h 01m |
| 50 mph (80.47 km/h) | 04h 01m |
| 60 mph (96.56 km/h) | 03h 21m |
| 70 mph (112.65 km/h) | 02h 52m |
| 80 mph (129 km/h) | 02h 30m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $26.77 | $53.55 |
| Mid-grade | $4.25 | $30.20 | $60.39 |
| Premium | $4.65 | $33.04 | $66.09 |
| Diesel | $5.30 | $37.66 | $75.32 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.