How far is Chillicothe, MO from St. Louis, MO?
The driving distance from Chillicothe, MO to St. Louis, MO is about 233.3 miles (375.4 km), with a travel time of about 03h 49m by car.
- The straight-line flight distance is about 196.9 miles (316.8 km).
- For a round trip, plan for roughly 07h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 49m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Slight Chance Showers And Thunderstorms
Showers And Thunderstorms Likely then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Chillicothe and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Chillicothe and St. Louis.
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1
Start on Locust Street
16 m · 4 sec · Locust Street
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2
Turn right onto West Calhoun Street
98 m · 18 sec · West Calhoun Street
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3
Turn left onto North Washington Street
1.6 mi · 4 min · North Washington Street
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4
Take the ramp left toward US 36 East, MO 110 East: Brookfield
975 ft · 13 sec
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5
Merge slight left onto Chicago-Kansas City Expressway
111.4 mi · 2 hr 9 min · Chicago-Kansas City Expressway
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6
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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7
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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8
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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9
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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10
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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11
Take the ramp right
37 m · 3 sec
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12
Merge slight left onto Avenue of the Saints
101.3 mi · 2 hr 1 min · Avenue of the Saints
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13
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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14
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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15
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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16
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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17
Turn right onto Market Street
956 ft · 25 sec · Market Street
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18
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Chillicothe and St. Louis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Chicago-Kansas City Expressway
Merge slight left onto Chicago-Kansas City Expressway
111 mi · 02h 09m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny then Slight Chance Showers And Thunderstorms leaving Chillicothe and Showers And Thunderstorms Likely then Chance Showers And Thunderstorms near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Chillicothe to St. Louis?
The road trip is about 233.3 miles (375.4 km) and usually takes 03h 49m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Hannibal is a useful midpoint, sitting about 117.6 miles from Chillicothe and 115.6 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 196.9 miles (316.8 km), while the road route adds roughly 36.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:20 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $31.04 one way or $62.07 round trip. Estimated CO2 is about 73.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Slight Chance Showers And Thunderstorms around Chillicothe and Showers And Thunderstorms Likely then Chance Showers And Thunderstorms near St. Louis.
Stop Ideas Near Hannibal
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Hannibal.
Quincy
Fort Madison station
Macomb
La Plata
Flight Path Map
This map shows the direct air route between Chillicothe and St. Louis. Straight-line distance: 196.87 mi (316.83 km).
#1 Chillicothe
City in Missouri
| Population | 8,915 |
| Coordinates | 39.7952900, -93.5524400 |
| Altitude | 243 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 375 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 46m |
| 40 mph (64.37 km/h) | 05h 49m |
| 50 mph (80.47 km/h) | 04h 39m |
| 60 mph (96.56 km/h) | 03h 53m |
| 70 mph (112.65 km/h) | 03h 19m |
| 80 mph (129 km/h) | 02h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $31.04 | $62.07 |
| Mid-grade | $4.25 | $35.00 | $70.00 |
| Premium | $4.65 | $38.30 | $76.60 |
| Diesel | $5.30 | $43.65 | $87.30 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.