How far is Cape Girardeau, MO from Waynesville, MO?
The driving distance from Cape Girardeau, MO to Waynesville, MO is about 211.4 miles (340.2 km), with a travel time of about 04h 08m by car.
- The straight-line flight distance is about 151.3 miles (243.5 km).
- For a round trip, plan for roughly 08h 17m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 08m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Jefferson County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Waynesville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Waynesville.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
84.9 mi · 1 hr 31 min
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5
Take the exit slight right toward MO M: Antonia, Barnhart
1759 ft · 44 sec
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6
At the end of the road, turn left
11.7 mi · 18 min
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7
Turn left
27 mi · 38 min
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8
Continue on West Gravois Avenue
1148 ft · 29 sec · West Gravois Avenue
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9
Turn right
1193 ft · 35 sec
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10
Take the exit left toward I 44 West: Rolla
1208 ft · 29 sec
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11
Merge slight left
78.8 mi · 1 hr 25 min
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12
Take the exit slight right toward I 44 Business: Waynesville
1099 ft · 23 sec
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13
Turn straight
1.9 mi · 4 min
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14
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Waynesville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 North
Merge slight left
84.9 mi · 01h 31m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Cape Girardeau and Showers And Thunderstorms Likely near Waynesville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Waynesville?
The road trip is about 211.4 miles (340.2 km) and usually takes 04h 08m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Scotsdale is a useful midpoint, sitting about 105.6 miles from Cape Girardeau and 105.8 miles from Waynesville.
How much longer is the road route than the straight-line distance?
The direct path is about 151.3 miles (243.5 km), while the road route adds roughly 60.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:42 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $28.13 one way or $56.26 round trip. Estimated CO2 is about 66.3 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Cape Girardeau and Showers And Thunderstorms Likely near Waynesville.
Stop Ideas Near Scotsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Scotsdale.
Kirkwood
Washington
Gateway Transportation Center
Alton
Flight Path Map
This map shows the direct air route between Cape Girardeau and Waynesville. Straight-line distance: 151.29 mi (243.47 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Waynesville
City in Pulaski County, Missouri, United States
| Population | 5,308 |
| Coordinates | 37.8286500, -92.2007200 |
| Altitude | 246 |
| Country | United States |
End: Waynesville (-92.20072, 37.82865)
Estimated Travel Time
Distance: 340 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 02m |
| 40 mph (64.37 km/h) | 05h 17m |
| 50 mph (80.47 km/h) | 04h 13m |
| 60 mph (96.56 km/h) | 03h 31m |
| 70 mph (112.65 km/h) | 03h 01m |
| 80 mph (129 km/h) | 02h 38m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $28.13 | $56.26 |
| Mid-grade | $4.25 | $31.73 | $63.45 |
| Premium | $4.65 | $34.72 | $69.44 |
| Diesel | $5.30 | $39.57 | $79.14 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 30, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.