How far is Cape Girardeau, MO from Neosho, MO?
The driving distance from Cape Girardeau, MO to Neosho, MO is about 342.5 miles (551.2 km), with a travel time of about 06h 44m by car.
- The straight-line flight distance is about 269 miles (432.9 km).
- For a round trip, plan for roughly 13h 29m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 44m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Howell County, Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Mostly Cloudy then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Neosho.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Neosho.
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1
Start on Broadway Street
2497 ft · 56 sec · Broadway Street
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2
Turn left onto North Sprigg Street
1.2 km · 2 min · North Sprigg Street
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3
Turn right onto Shawnee Parkway
1.6 mi · 3 min · Shawnee Parkway
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4
Turn left onto South Kingshighway
1.9 mi · 3 min · South Kingshighway
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5
Keep slight left to continue on I 55 South, US 61 South: Sikeston
27.2 mi · 29 min
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6
Take the exit slight right toward US 60 West: Dexter, Poplar Bluff
2865 ft · 1 min
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7
Merge slight left
45.4 mi · 52 min
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8
Keep slight left
5.5 mi · 6 min
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9
Take the exit slight right toward US 60 West, US 67 North: Springfield, Saint Louis
4.5 mi · 6 min
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10
Take the exit slight right
186.3 mi · 3 hr 39 min
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11
Keep slight left to continue on I 44 West: Joplin
1.3 km · 2 min
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12
Merge slight left onto Captain Aaron J Eidem Memorial Highway
50.1 mi · 54 min · Captain Aaron J Eidem Memorial Highway
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13
Take the exit slight right toward MO 59 South: Diamond
1302 ft · 37 sec
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14
Merge slight left onto George Washington Carver Memorial Highway
12 mi · 18 min · George Washington Carver Memorial Highway
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15
Turn slight right
1575 ft · 59 sec
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16
Turn right
4.3 mi · 6 min
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17
Turn left onto West Coler Street
111 m · 9 sec · West Coler Street
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18
Turn right onto North Jefferson Street
1489 ft · 46 sec · North Jefferson Street
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19
Turn left onto West Main Street
156 m · 22 sec · West Main Street
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20
Arrive at your destination
0 m · 1 sec · East Main Street
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Neosho.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
US 60 West
Take the exit slight right
186 mi · 03h 39m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Cape Girardeau and Mostly Cloudy then Slight Chance Showers And Thunderstorms near Neosho.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Neosho?
The road trip is about 342.5 miles (551.2 km) and usually takes 06h 44m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Mountain View is a useful midpoint, sitting about 171 miles from Cape Girardeau and 171.4 miles from Neosho.
How much longer is the road route than the straight-line distance?
The direct path is about 269 miles (432.9 km), while the road route adds roughly 73.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.59 one way or $91.18 round trip. Estimated CO2 is about 107.4 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Cape Girardeau and Mostly Cloudy then Slight Chance Showers And Thunderstorms near Neosho.
Flight Path Map
This map shows the direct air route between Cape Girardeau and Neosho. Straight-line distance: 268.98 mi (432.88 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Neosho
City in Newton County, Missouri, United States
| Population | 12,116 |
| Coordinates | 36.8689600, -94.3680000 |
| Altitude | 316 |
| Country | United States |
End: Neosho (-94.368, 36.86896)
Estimated Travel Time
Distance: 551 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 24m |
| 40 mph (64.37 km/h) | 08h 33m |
| 50 mph (80.47 km/h) | 06h 50m |
| 60 mph (96.56 km/h) | 05h 42m |
| 70 mph (112.65 km/h) | 04h 53m |
| 80 mph (129 km/h) | 04h 16m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $45.59 | $91.18 |
| Mid-grade | $4.25 | $51.42 | $102.84 |
| Premium | $4.65 | $56.27 | $112.53 |
| Diesel | $5.30 | $64.13 | $128.25 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.