How far is Neosho, MO from Cape Girardeau, MO?
Fastest route
The distance between Neosho, Missouri 64850 and Cape Girardeau, Missouri is approximately 343 miles (552 kilometers). The fastest route, considering current traffic conditions, is via US-60 E. Here are some tips and suggestions for the journey:
Directions
- Head east on E Main St toward S Washington St.
- Turn right onto Hamilton St.
- Turn left onto State Hwy 86 E/E McKinney St and continue to follow State Hwy 86 E.
- Follow I-44 E, US-60 E, and I-55 N to Southern Expy in Cape Girardeau.
- Keep left to continue on MO-59 N.
- Slight right to merge onto I-44 E toward Springfield.
- Take exit 69 for MO-360 E/James Riv Frwy toward To Rte 60 and continue onto James River Fwy E.
Tips & Suggestions
- 🚗 Start by heading east on E Main St toward S Washington St.
- 🛣️ Take State Hwy 86 E to US-60 E.
- ⛽ Make sure to have enough fuel for the journey.
- 🚦 Keep an eye on traffic conditions, as they may affect the route.
- 📱 Consider using a navigation app to stay updated on the road conditions.
- 🍴 Plan for meal stops along the way to Cape Girardeau.
- 🚧 Be aware of any road construction or detours that may impact your journey.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 30m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Howell County, Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy then Slight Chance Showers And Thunderstorms
Sunny
Driving Route Map
The map below follows the saved road route between Neosho and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Neosho and Cape Girardeau.
-
1
Start on East Main Street
66 m · 15 sec · East Main Street
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2
Turn left onto South Washington Street
1506 ft · 53 sec · South Washington Street
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3
At the end of the road, turn left onto East Coler Street
1106 ft · 26 sec · East Coler Street
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4
Turn right onto North College Street
1.3 mi · 2 min · North College Street
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5
Continue on Elwood Junction Road
3.1 mi · 4 min · Elwood Junction Road
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6
Turn left
1382 ft · 51 sec
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7
Turn straight
11.7 mi · 17 min
-
8
Take the ramp slight right toward I 44 East: Springfield
2007 ft · 43 sec
-
9
Merge slight left onto Congressman Gene Taylor Highway
50 mi · 54 min · Congressman Gene Taylor Highway
-
10
Take the exit slight right toward MO 360 East
1463 ft · 31 sec
-
11
Continue on James River Freeway
14.4 mi · 17 min · James River Freeway
-
12
Continue straight
81.3 mi · 1 hr 35 min
-
13
Keep slight left to continue on US 60 East: Mountain View, Poplar Bluff
90.4 mi · 1 hr 47 min
-
14
Keep slight right
4.8 mi · 6 min
-
15
Turn straight onto North Westwood Boulevard
823 ft · 14 sec · North Westwood Boulevard
-
16
Turn slight left
84 m · 12 sec
-
17
Turn left
756 ft · 16 sec
-
18
Take the ramp right
1102 ft · 27 sec
-
19
Merge slight left
51 mi · 59 min
-
20
Take the exit slight right toward I 55 North: Saint Louis
1793 ft · 44 sec
-
21
Merge slight left
27.4 mi · 29 min
-
22
Keep slight right to continue on US 61, I 55 Business: Cape Girardeau
2 mi · 3 min
-
23
Turn right onto Shawnee Parkway
1.6 mi · 3 min · Shawnee Parkway
-
24
Turn left onto South Sprigg Street
1.3 km · 2 min · South Sprigg Street
-
25
Turn right onto Broadway Street
2497 ft · 51 sec · Broadway Street
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26
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Neosho and Cape Girardeau.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
US 60 East
Keep slight left to continue on US 60 East: Mountain View, Poplar Bluff
90.4 mi · 01h 47m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy then Slight Chance Showers And Thunderstorms leaving Neosho and Sunny near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Neosho to Cape Girardeau?
The road trip is about 343.5 miles (552.8 km) and usually takes 05h 30m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Mountain View is a useful midpoint, sitting about 171.1 miles from Neosho and 172.3 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 269 miles (432.9 km), while the road route adds roughly 74.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:58 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.70 one way or $91.41 round trip. Estimated CO2 is about 107.7 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy then Slight Chance Showers And Thunderstorms around Neosho and Sunny near Cape Girardeau.
Flight Path Map
This map shows the direct air route between Neosho and Cape Girardeau. Straight-line distance: 268.98 mi (432.88 km).
#1 Neosho
City in Newton County, Missouri, United States
| Population | 12,116 |
| Coordinates | 36.8689600, -94.3680000 |
| Altitude | 316 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 553 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 26m |
| 40 mph (64.37 km/h) | 08h 35m |
| 50 mph (80.47 km/h) | 06h 52m |
| 60 mph (96.56 km/h) | 05h 43m |
| 70 mph (112.65 km/h) | 04h 54m |
| 80 mph (129 km/h) | 04h 17m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $45.70 | $91.41 |
| Mid-grade | $4.25 | $51.55 | $103.09 |
| Premium | $4.65 | $56.41 | $112.81 |
| Diesel | $5.30 | $64.28 | $128.57 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.