How far is Cape Girardeau, MO from Glendale, MO?
The driving distance from Cape Girardeau, MO to Glendale, MO is about 81.3 miles (130.8 km), with a travel time of about 01h 49m by car.
- The straight-line flight distance is about 65.4 miles (105.3 km).
- For a round trip, plan for roughly 03h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 49m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in New Madrid County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Glendale.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Glendale.
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1
Start on Broadway Street
2497 ft · 56 sec · Broadway Street
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2
Turn left onto North Sprigg Street
1.2 km · 2 min · North Sprigg Street
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3
Turn right onto Shawnee Parkway
1.6 mi · 3 min · Shawnee Parkway
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4
Turn left onto South Kingshighway
1.9 mi · 3 min · South Kingshighway
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5
Keep slight left to continue on I 55 South, US 61 South: Sikeston
37.3 mi · 40 min
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6
Continue straight
23.3 mi · 25 min
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7
Take the exit slight right toward MO 162: Portageville
1184 ft · 25 sec
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8
Turn right
3079 ft · 54 sec
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9
Turn right
1 mi · 2 min
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10
Turn left
9.8 mi · 17 min
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11
Turn left onto County Road 277
1.1 mi · 4 min · County Road 277
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12
Turn right onto County Road 281
1.7 mi · 7 min · County Road 281
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13
Turn right onto County Road 282
1 mi · 4 min · County Road 282
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14
Continue straight
2310 ft · 1 min
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15
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Glendale.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Keep slight left to continue on I 55 South, US 61 South: Sikeston
37.3 mi · 00h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Sunny leaving Cape Girardeau and Sunny near Glendale.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Glendale?
The road trip is about 81.3 miles (130.8 km) and usually takes 01h 49m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Matthews is a useful midpoint, sitting about 40.7 miles from Cape Girardeau and 40.6 miles from Glendale.
How much longer is the road route than the straight-line distance?
The direct path is about 65.4 miles (105.3 km), while the road route adds roughly 15.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 2:50 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $10.82 one way or $21.65 round trip. Estimated CO2 is about 25.5 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Cape Girardeau and Sunny near Glendale.
Stop Ideas Near Matthews
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Matthews.
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Flight Path Map
This map shows the direct air route between Cape Girardeau and Glendale. Straight-line distance: 65.46 mi (105.35 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Glendale
City in Missouri
| Population | 5,863 |
| Coordinates | 36.4106200, -89.9056400 |
| Altitude | 82 |
| Country | United States |
End: Glendale (-89.90564, 36.41062)
Estimated Travel Time
Distance: 131 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 02h 42m |
| 40 mph (64.37 km/h) | 02h 01m |
| 50 mph (80.47 km/h) | 01h 37m |
| 60 mph (96.56 km/h) | 01h 21m |
| 70 mph (112.65 km/h) | 01h 09m |
| 80 mph (129 km/h) | 01h 00m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $10.82 | $21.65 |
| Mid-grade | $4.25 | $12.21 | $24.41 |
| Premium | $4.65 | $13.36 | $26.71 |
| Diesel | $5.30 | $15.22 | $30.44 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.