How far is Cape Girardeau, MO from Gladstone, MO?
The driving distance from Cape Girardeau, MO to Gladstone, MO is about 355.3 miles (571.8 km), with a travel time of about 06h 52m by car.
- The straight-line flight distance is about 303 miles (487.7 km).
- For a round trip, plan for roughly 13h 44m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 52m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Cape Girardeau and Gladstone.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau and Gladstone.
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1
Start on Broadway Street
2 mi · 4 min · Broadway Street
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2
Turn right onto North Kingshighway
3.6 mi · 6 min · North Kingshighway
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3
Take the ramp slight right toward I 55 North: Saint Louis
1606 ft · 39 sec
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4
Merge slight left
95.1 mi · 1 hr 42 min
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5
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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7
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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8
Continue on I 270 West
1.2 km · 1 min
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9
Merge slight left
11.5 mi · 14 min
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10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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13
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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15
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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16
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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21
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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22
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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23
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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24
Continue on George Brett Super Highway
1.4 km · 58 sec · George Brett Super Highway
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25
Take the exit slight right toward I 435 North, US 24 East: Des Moines
1.1 mi · 2 min
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26
Merge slight left onto Lamar Hunt Memorial Highway
4.1 mi · 5 min · Lamar Hunt Memorial Highway
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27
Take the exit slight right toward East Front Street
746 ft · 18 sec
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28
Turn left onto East Front Street, Riverfront Park Access
54 m · 5 sec
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29
Continue on East Front Street
1.3 mi · 3 min · East Front Street
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30
Turn right onto North Chouteau Trafficway
1.6 mi · 3 min · North Chouteau Trafficway
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31
Continue on Northeast Chouteau Parkway
1.7 mi · 3 min · Northeast Chouteau Parkway
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32
Continue on Northeast Chouteau Trafficway
1.6 mi · 3 min · Northeast Chouteau Trafficway
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33
Turn right onto North Antioch Road
3141 ft · 1 min · North Antioch Road
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34
Turn left onto Northeast 60th Street
1475 ft · 1 min · Northeast 60th Street
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35
At the end of the road, turn right onto North Howard Avenue
105 m · 20 sec · North Howard Avenue
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36
Turn left onto Northeast 60th Terrace
114 m · 22 sec · Northeast 60th Terrace
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37
Turn sharp right onto North Garfield Avenue
41 m · 6 sec · North Garfield Avenue
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38
Arrive at your destination
0 m · 1 sec · North Garfield Avenue
Car Route Details
A richer read on the saved driving route between Cape Girardeau and Gladstone.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Merge slight left
95.1 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Showers And Thunderstorms leaving Cape Girardeau and Chance Showers And Thunderstorms near Gladstone.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Girardeau to Gladstone?
The road trip is about 355.3 miles (571.8 km) and usually takes 06h 52m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
New Florence is a useful midpoint, sitting about 177.5 miles from Cape Girardeau and 177.8 miles from Gladstone.
How much longer is the road route than the straight-line distance?
The direct path is about 303 miles (487.7 km), while the road route adds roughly 52.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $47.29 one way or $94.58 round trip. Estimated CO2 is about 111.4 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Cape Girardeau and Chance Showers And Thunderstorms near Gladstone.
Stop Ideas Near New Florence
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to New Florence.
Hermann
Washington
Jefferson City
Kirkwood
Flight Path Map
This map shows the direct air route between Cape Girardeau and Gladstone. Straight-line distance: 303.04 mi (487.7 km).
#1 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
#2 Gladstone
City in Missouri, USA
| Population | 27,677 |
| Coordinates | 39.2038900, -94.5546800 |
| Altitude | 287 |
| Country | United States |
End: Gladstone (-94.55468, 39.20389)
Estimated Travel Time
Distance: 572 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 50m |
| 40 mph (64.37 km/h) | 08h 52m |
| 50 mph (80.47 km/h) | 07h 06m |
| 60 mph (96.56 km/h) | 05h 55m |
| 70 mph (112.65 km/h) | 05h 04m |
| 80 mph (129 km/h) | 04h 25m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $47.29 | $94.58 |
| Mid-grade | $4.25 | $53.33 | $106.67 |
| Premium | $4.65 | $58.36 | $116.72 |
| Diesel | $5.30 | $66.51 | $133.02 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.