How far is Waynesboro, TN from Knoxville, TN?
The driving distance from Waynesboro, TN to Knoxville, TN is about 275.2 miles (442.9 km), with a travel time of about 04h 24m by car.
- The straight-line flight distance is about 220.2 miles (354.4 km).
- For a round trip, plan for roughly 08h 49m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Wilson County, Tennessee, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Driving Route Map
The map below follows the saved road route between Waynesboro and Knoxville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Waynesboro and Knoxville.
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1
Start on North Main Street
68 m · 7 sec · North Main Street
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2
Turn right onto Hill Street
60 m · 3 sec · Hill Street
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3
Turn straight onto Dexter L Woods Memorial Boulevard
1.2 mi · 2 min · Dexter L Woods Memorial Boulevard
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4
Continue on United States Route 64
14.4 mi · 16 min · United States Route 64
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5
Turn left
4.9 mi · 9 min
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6
Turn straight
10 mi · 18 min
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7
Continue straight
1.3 mi · 2 min
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8
Turn straight
1.1 km · 1 min
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9
At the end of the road, turn left onto Lawrenceburg Highway
30.3 mi · 35 min · Lawrenceburg Highway
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10
Take the exit left
1845 ft · 45 sec
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11
Merge slight left
12.1 mi · 13 min
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12
Take the exit slight right toward I 840: Memphis, Knoxville
1120 ft · 17 sec
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13
Keep slight right to continue on 840: Knoxville, Murfreesboro
2889 ft · 42 sec
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14
Merge slight left onto Tennessee National Guard Parkway
45 mi · 48 min · Tennessee National Guard Parkway
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15
Keep slight right to continue on I 40 East: Knoxville, Lebanon
1.2 km · 2 min
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16
Merge slight left
149.1 mi · 2 hr 42 min
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17
Keep slight left
2.9 mi · 4 min
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18
Take the exit slight right toward Convention Center, East Tennessee History Center, Museum of Art
2116 ft · 28 sec
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19
Keep slight left to continue on Convention Center, East Tennessee History Center, Museum of Art
2403 ft · 56 sec
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20
Continue on Henley Street
1238 ft · 27 sec · Henley Street
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21
Continue on Henley Street
78 m · 12 sec · Henley Street
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22
Arrive at your destination
0 m · 1 sec · Henley Street
Car Route Details
A richer read on the saved driving route between Waynesboro and Knoxville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 40 East
Merge slight left
149 mi · 02h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Waynesboro and Sunny near Knoxville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Waynesboro to Knoxville?
The road trip is about 275.2 miles (442.9 km) and usually takes 04h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Watertown is a useful midpoint, sitting about 137.4 miles from Waynesboro and 137.9 miles from Knoxville.
How much longer is the road route than the straight-line distance?
The direct path is about 220.2 miles (354.4 km), while the road route adds roughly 55 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:10 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $36.62 one way or $73.23 round trip. Estimated CO2 is about 86.3 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Waynesboro and Knoxville, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Sunny around Waynesboro and Sunny near Knoxville.
Stop Ideas Near Watertown
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Watertown.
Nashville, TN
Flight Path Map
This map shows the direct air route between Waynesboro and Knoxville. Straight-line distance: 220.2 mi (354.37 km).
#1 Waynesboro
City in Tennessee
| Population | 2,371 |
| Coordinates | 35.3195200, -87.7622500 |
| Altitude | 228 |
| Country | United States |
#2 Knoxville
The most populous city in Tennessee.
| Population | 190,223 |
| Coordinates | 35.9606400, -83.9207400 |
| Altitude | 276 |
| Country | United States |
End: US 11 (-83.920795, 35.960617)
Estimated Travel Time
Distance: 443 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 10m |
| 40 mph (64.37 km/h) | 06h 52m |
| 50 mph (80.47 km/h) | 05h 30m |
| 60 mph (96.56 km/h) | 04h 35m |
| 70 mph (112.65 km/h) | 03h 55m |
| 80 mph (129 km/h) | 03h 26m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $36.62 | $73.23 |
| Mid-grade | $4.25 | $41.30 | $82.59 |
| Premium | $4.65 | $45.19 | $90.38 |
| Diesel | $5.30 | $51.50 | $103.00 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Tennessee · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.