How far is Tampa, FL from North Key Largo, FL?
The driving distance from Tampa, FL to North Key Largo, FL is about 313.8 miles (505 km), with a travel time of about 05h 55m by car.
- The straight-line flight distance is about 227.4 miles (365.9 km).
- For a round trip, plan for roughly 11h 50m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 55m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Collier County, Florida
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy then Chance Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Tampa and North Key Largo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Tampa and North Key Largo.
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1
Start on East Kennedy Boulevard
36 m · 11 sec · East Kennedy Boulevard
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2
Turn left onto North Tampa Street
90 m · 13 sec · North Tampa Street
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3
Turn left onto East Jackson Street
2823 ft · 2 min · East Jackson Street
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4
Keep slight left to continue on East Jackson Street
21 m · 4 sec · East Jackson Street
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5
Turn left onto North Nebraska Avenue
123 m · 10 sec · North Nebraska Avenue
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6
Take the ramp slight right toward FL 618 Toll East: Brandon
853 ft · 21 sec
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7
Merge slight left onto Lee Roy Selmon Expressway
7.8 mi · 9 min · Lee Roy Selmon Expressway
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8
Keep slight right to continue on I 75 South: Naples
2585 ft · 34 sec
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9
Merge slight left
55.8 mi · 1 hr
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10
Keep slight left
175.7 mi · 3 hr 8 min
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11
Take the exit slight right toward US 27: Miami, South Bay
1118 ft · 21 sec
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12
Keep slight right to continue on US 27 South: Miami
2407 ft · 59 sec
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13
Merge slight left
9.2 mi · 11 min
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14
Keep slight right
8.6 mi · 11 min
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15
Take the exit right toward Florida's Turnpike South: Homestead, Key West
1324 ft · 32 sec
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16
Merge slight left onto Homestead Extension of Florida's Turnpike
34.5 mi · 41 min · Homestead Extension of Florida's Turnpike
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17
Keep slight left
2930 ft · 1 min
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18
Merge slight left onto Dixie Highway
1 mi · 2 min · Dixie Highway
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19
Turn left onto Card Sound Road
16.5 mi · 23 min · Card Sound Road
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20
Turn right
1.7 mi · 3 min
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21
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Tampa and North Key Largo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 75 South
Keep slight left
176 mi · 03h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy then Chance Showers And Thunderstorms leaving Tampa and Chance Showers And Thunderstorms near North Key Largo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Tampa to North Key Largo?
The road trip is about 313.8 miles (505 km) and usually takes 05h 55m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Vineyards is a useful midpoint, sitting about 157.1 miles from Tampa and 156.7 miles from North Key Largo.
How much longer is the road route than the straight-line distance?
The direct path is about 227.4 miles (365.9 km), while the road route adds roughly 86.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 5:10 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.92 one way or $91.84 round trip. Estimated CO2 is about 98.4 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy then Chance Showers And Thunderstorms around Tampa and Chance Showers And Thunderstorms near North Key Largo.
Stop Ideas Near Vineyards
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Vineyards.
Fort Myers, Florida
Port Charlotte, Florida
Flight Path Map
This map shows the direct air route between Tampa and North Key Largo. Straight-line distance: 227.34 mi (365.87 km).
#1 Tampa
The third most populous city in Florida and the center of the Tampa metropolitan area.
| Population | 407,599 |
| Coordinates | 27.9475200, -82.4584300 |
| Altitude | 1 |
| Country | United States |
#2 North Key Largo
Census-designated place in Monroe County, Florida, United States
| Population | 1,244 |
| Coordinates | 25.2673400, -80.3233900 |
| Altitude | 0 |
| Country | United States |
End: North Key Largo (-80.32339, 25.26734)
Estimated Travel Time
Distance: 505 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 27m |
| 40 mph (64.37 km/h) | 07h 50m |
| 50 mph (80.47 km/h) | 06h 16m |
| 60 mph (96.56 km/h) | 05h 13m |
| 70 mph (112.65 km/h) | 04h 28m |
| 80 mph (129 km/h) | 03h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $45.92 | $91.84 |
| Mid-grade | $4.60 | $50.88 | $101.76 |
| Premium | $4.90 | $54.20 | $108.40 |
| Diesel | $4.35 | $48.15 | $96.31 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.