How far is St. Louis, MO from Vandalia, MO?
The driving distance from St. Louis, MO to Vandalia, MO is about 103.1 miles (166 km), with a travel time of about 02h 08m by car.
- The straight-line flight distance is about 83.9 miles (135 km).
- For a round trip, plan for roughly 04h 16m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 08m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Lincoln County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between St. Louis and Vandalia.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Vandalia.
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1
Start on Market Street
1.6 mi · 3 min · Market Street
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2
Take the ramp slight left toward I 64 West, US 40 West: Wentzville
1531 ft · 24 sec
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3
Merge slight left onto Jack Buck Memorial Highway
4.3 mi · 6 min · Jack Buck Memorial Highway
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4
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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5
Continue on Avenue of the Saints
74.4 mi · 1 hr 29 min · Avenue of the Saints
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6
Take the exit slight right toward US 54: Mexico, Louisiana
1540 ft · 39 sec
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7
Turn left
11.7 mi · 15 min
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8
Keep slight left
4.9 mi · 7 min
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9
Turn right onto North Main Street
15 m · 1 sec · North Main Street
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10
Arrive at your destination
0 m · 1 sec · North Main Street
Car Route Details
A richer read on the saved driving route between St. Louis and Vandalia.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Avenue of the Saints
Continue on Avenue of the Saints
74.4 mi · 01h 29m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Sunny leaving St. Louis and Sunny near Vandalia.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Vandalia?
The road trip is about 103.1 miles (166 km) and usually takes 02h 08m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Moscow Mills is a useful midpoint, sitting about 51.5 miles from St. Louis and 51.6 miles from Vandalia.
How much longer is the road route than the straight-line distance?
The direct path is about 83.9 miles (135 km), while the road route adds roughly 19.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 2:14 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $13.73 one way or $27.45 round trip. Estimated CO2 is about 32.3 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around St. Louis and Sunny near Vandalia.
Stop Ideas Near Moscow Mills
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Moscow Mills.
Washington
Hermann
Kirkwood
Alton
Flight Path Map
This map shows the direct air route between St. Louis and Vandalia. Straight-line distance: 83.89 mi (135.01 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Vandalia
City in Audrain and Ralls Counties, Missouri, USA
| Population | 3,496 |
| Coordinates | 39.3108700, -91.4884900 |
| Altitude | 232 |
| Country | United States |
End: Vandalia (-91.48849, 39.31087)
Estimated Travel Time
Distance: 166 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 26m |
| 40 mph (64.37 km/h) | 02h 34m |
| 50 mph (80.47 km/h) | 02h 03m |
| 60 mph (96.56 km/h) | 01h 43m |
| 70 mph (112.65 km/h) | 01h 28m |
| 80 mph (129 km/h) | 01h 17m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $13.73 | $27.45 |
| Mid-grade | $4.25 | $15.48 | $30.96 |
| Premium | $4.65 | $16.94 | $33.88 |
| Diesel | $5.30 | $19.31 | $38.61 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 25, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.