How far is Vandalia, MO from St. Louis, MO?
The driving distance from Vandalia, MO to St. Louis, MO is about 103.3 miles (166.3 km), with a travel time of about 01h 43m by car.
- The straight-line flight distance is about 83.9 miles (135 km).
- For a round trip, plan for roughly 03h 27m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 01h 43m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Lincoln County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Vandalia and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Vandalia and St. Louis.
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1
Start on North Main Street
15 m · 6 sec · North Main Street
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2
Turn left onto US 54
16.2 mi · 21 min · US 54
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3
Take the ramp right toward US 61 South: Saint Louis
1740 ft · 43 sec
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4
Merge slight left onto Avenue of the Saints
74.5 mi · 1 hr 30 min · Avenue of the Saints
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5
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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6
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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7
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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8
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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9
Turn right onto Market Street
956 ft · 27 sec · Market Street
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10
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Vandalia and St. Louis.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Avenue of the Saints
Merge slight left onto Avenue of the Saints
74.5 mi · 01h 30m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Sunny leaving Vandalia and Mostly Sunny near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Vandalia to St. Louis?
The road trip is about 103.3 miles (166.3 km) and usually takes 01h 43m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Moscow Mills is a useful midpoint, sitting about 51.6 miles from Vandalia and 51.8 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 83.9 miles (135 km), while the road route adds roughly 19.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 3:02 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $13.76 one way or $27.53 round trip. Estimated CO2 is about 32.4 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Vandalia and Mostly Sunny near St. Louis.
Stop Ideas Near Moscow Mills
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Moscow Mills.
Washington
Hermann
Kirkwood
Alton
Flight Path Map
This map shows the direct air route between Vandalia and St. Louis. Straight-line distance: 83.89 mi (135.01 km).
#1 Vandalia
City in Audrain and Ralls Counties, Missouri, USA
| Population | 3,496 |
| Coordinates | 39.3108700, -91.4884900 |
| Altitude | 232 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 166 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 03h 26m |
| 40 mph (64.37 km/h) | 02h 35m |
| 50 mph (80.47 km/h) | 02h 03m |
| 60 mph (96.56 km/h) | 01h 43m |
| 70 mph (112.65 km/h) | 01h 28m |
| 80 mph (129 km/h) | 01h 17m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $13.76 | $27.53 |
| Mid-grade | $4.25 | $15.52 | $31.05 |
| Premium | $4.65 | $16.99 | $33.97 |
| Diesel | $5.30 | $19.36 | $38.72 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 25, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.