How far is St. Louis, MO from Memphis, MO?
The driving distance from St. Louis, MO to Memphis, MO is about 203.4 miles (327.4 km), with a travel time of about 04h 17m by car.
- The straight-line flight distance is about 164.5 miles (264.7 km).
- For a round trip, plan for roughly 08h 34m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 17m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Patchy Frost then Sunny
Driving Route Map
The map below follows the saved road route between St. Louis and Memphis.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and Memphis.
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1
Start on Market Street
1.6 mi · 3 min · Market Street
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2
Take the ramp slight left toward I 64 West, US 40 West: Wentzville
1531 ft · 24 sec
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3
Merge slight left onto Jack Buck Memorial Highway
4.3 mi · 6 min · Jack Buck Memorial Highway
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4
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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5
Continue on Avenue of the Saints
101.2 mi · 2 hr 1 min · Avenue of the Saints
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6
Take the exit slight left
76 m · 15 sec
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7
Turn left onto Paris Gravel Road
2645 ft · 1 min · Paris Gravel Road
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8
Keep slight right to continue on County Road 422
85 m · 9 sec · County Road 422
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9
Turn right onto Veterans Road
3.2 mi · 6 min · Veterans Road
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10
Turn left
1.7 mi · 2 min
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11
Turn left onto Avenue of the Saints
17 mi · 20 min · Avenue of the Saints
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12
Take the exit slight right toward Avenue of the Saints
33.3 mi · 39 min · Avenue of the Saints
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13
Take the exit slight right toward US 136: Wayland, Kahoka
1561 ft · 48 sec
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14
Turn left
33.8 mi · 50 min
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15
Turn right onto South Market Street
2417 ft · 54 sec · South Market Street
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16
Turn left onto East Monroe Street
530 ft · 11 sec · East Monroe Street
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17
Arrive at your destination
0 m · 1 sec · West Monroe Street
Car Route Details
A richer read on the saved driving route between St. Louis and Memphis.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Avenue of the Saints
Continue on Avenue of the Saints
101 mi · 02h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving St. Louis and Patchy Frost then Sunny near Memphis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to Memphis?
The road trip is about 203.4 miles (327.4 km) and usually takes 04h 17m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
New London is a useful midpoint, sitting about 101.7 miles from St. Louis and 101.8 miles from Memphis.
How much longer is the road route than the straight-line distance?
The direct path is about 164.5 miles (264.7 km), while the road route adds roughly 38.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:26 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $27.08 one way or $54.15 round trip. Estimated CO2 is about 63.8 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around St. Louis and Patchy Frost then Sunny near Memphis.
Stop Ideas Near New London
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to New London.
Quincy
Hermann
La Plata
Macomb
Flight Path Map
This map shows the direct air route between St. Louis and Memphis. Straight-line distance: 164.46 mi (264.68 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 Memphis
City in Scotland County, Missouri, United States
| Population | 1,815 |
| Coordinates | 40.4578100, -92.1712900 |
| Altitude | 244 |
| Country | United States |
End: Memphis (-92.17129, 40.45781)
Estimated Travel Time
Distance: 327 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 46m |
| 40 mph (64.37 km/h) | 05h 05m |
| 50 mph (80.47 km/h) | 04h 04m |
| 60 mph (96.56 km/h) | 03h 23m |
| 70 mph (112.65 km/h) | 02h 54m |
| 80 mph (129 km/h) | 02h 32m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $27.08 | $54.15 |
| Mid-grade | $4.25 | $30.54 | $61.07 |
| Premium | $4.65 | $33.42 | $66.83 |
| Diesel | $5.30 | $38.08 | $76.17 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 02, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.