How far is Memphis, MO from St. Louis, MO?
The driving distance from Memphis, MO to St. Louis, MO is about 204.1 miles (328.4 km), with a travel time of about 03h 25m by car.
- The straight-line flight distance is about 164.5 miles (264.7 km).
- For a round trip, plan for roughly 06h 51m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 25m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Pike County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Patchy Frost then Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Memphis and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Memphis and St. Louis.
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1
Start on West Monroe Street
530 ft · 13 sec · West Monroe Street
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2
Turn right onto South Market Street
2417 ft · 49 sec · South Market Street
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3
Turn left onto Grand Avenue
33.7 mi · 50 min · Grand Avenue
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4
Take the ramp right toward MO 27 South: Hannibal
1519 ft · 42 sec
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5
Merge slight left onto Avenue of the Saints
46.3 mi · 54 min · Avenue of the Saints
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6
Continue on Avenue of the Saints
3.9 mi · 5 min · Avenue of the Saints
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7
Turn right
1.7 mi · 2 min
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8
Turn right onto Veterans Road
3.2 mi · 6 min · Veterans Road
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9
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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10
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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11
Take the ramp right
37 m · 3 sec
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12
Merge slight left onto Avenue of the Saints
101.3 mi · 2 hr 1 min · Avenue of the Saints
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13
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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14
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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15
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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16
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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17
Turn right onto Market Street
956 ft · 25 sec · Market Street
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18
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Memphis and St. Louis.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Avenue of the Saints
Merge slight left onto Avenue of the Saints
101 mi · 02h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Patchy Frost then Sunny leaving Memphis and Mostly Sunny near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Memphis to St. Louis?
The road trip is about 204.1 miles (328.4 km) and usually takes 03h 25m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Frankford is a useful midpoint, sitting about 101.8 miles from Memphis and 102.3 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 164.5 miles (264.7 km), while the road route adds roughly 39.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:08 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $27.15 one way or $54.30 round trip. Estimated CO2 is about 64 kg one way.
What should you check before leaving?
Before you leave, expect Patchy Frost then Sunny around Memphis and Mostly Sunny near St. Louis.
Stop Ideas Near Frankford
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Frankford.
Quincy
Hermann
Washington
La Plata
Flight Path Map
This map shows the direct air route between Memphis and St. Louis. Straight-line distance: 164.46 mi (264.68 km).
#1 Memphis
City in Scotland County, Missouri, United States
| Population | 1,815 |
| Coordinates | 40.4578100, -92.1712900 |
| Altitude | 244 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 328 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 47m |
| 40 mph (64.37 km/h) | 05h 06m |
| 50 mph (80.47 km/h) | 04h 04m |
| 60 mph (96.56 km/h) | 03h 24m |
| 70 mph (112.65 km/h) | 02h 54m |
| 80 mph (129 km/h) | 02h 32m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $27.15 | $54.30 |
| Mid-grade | $4.25 | $30.62 | $61.24 |
| Premium | $4.65 | $33.51 | $67.02 |
| Diesel | $5.30 | $38.19 | $76.38 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 02, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.