How far is St. Louis, MO from East Prairie, MO?
The driving distance from St. Louis, MO to East Prairie, MO is about 163.8 miles (263.6 km), with a travel time of about 03h 04m by car.
- The straight-line flight distance is about 135.1 miles (217.5 km).
- For a round trip, plan for roughly 06h 08m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 04m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between St. Louis and East Prairie.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and East Prairie.
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1
Start on Market Street
26 m · 4 sec · Market Street
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2
Turn left onto South Tucker Boulevard
1.3 mi · 4 min · South Tucker Boulevard
-
3
Turn straight onto Gravois Avenue
1619 ft · 46 sec · Gravois Avenue
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4
Take the ramp left toward I 55 South: Memphis
626 ft · 15 sec
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5
Merge slight left
141.5 mi · 2 hr 34 min
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6
Take the exit slight right toward I 57 North, US 60 East: Chicago
1264 ft · 31 sec
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7
Merge slight left
10.3 mi · 11 min
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8
Take the exit slight right toward I 57 Business North, MO 105: Charleston, East Prairie
1111 ft · 27 sec
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9
Turn right onto South Main Street
9.4 mi · 13 min · South Main Street
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10
Turn left onto North Washington Street
1650 ft · 38 sec · North Washington Street
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11
Turn left onto East Main Street
26 m · 4 sec · East Main Street
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12
Arrive at your destination
0 m · 1 sec · East Main Street
Car Route Details
A richer read on the saved driving route between St. Louis and East Prairie.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Merge slight left
141 mi · 02h 34m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving St. Louis and Sunny near East Prairie.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to East Prairie?
The road trip is about 163.8 miles (263.6 km) and usually takes 03h 04m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Perryville is a useful midpoint, sitting about 82 miles from St. Louis and 81.8 miles from East Prairie.
How much longer is the road route than the straight-line distance?
The direct path is about 135.1 miles (217.5 km), while the road route adds roughly 28.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:52 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $21.80 one way or $43.59 round trip. Estimated CO2 is about 51.4 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around St. Louis and Sunny near East Prairie.
Stop Ideas Near Perryville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Perryville.
Carbondale station
Du Quoin
Marion, IL
Vienna, IL
Flight Path Map
This map shows the direct air route between St. Louis and East Prairie. Straight-line distance: 135.15 mi (217.5 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 East Prairie
City in Mississippi County, Missouri, United States
| Population | 2,924 |
| Coordinates | 36.7797800, -89.3856300 |
| Altitude | 93 |
| Country | United States |
End: East Prairie (-89.38563, 36.77978)
Estimated Travel Time
Distance: 264 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 27m |
| 40 mph (64.37 km/h) | 04h 05m |
| 50 mph (80.47 km/h) | 03h 16m |
| 60 mph (96.56 km/h) | 02h 43m |
| 70 mph (112.65 km/h) | 02h 20m |
| 80 mph (129 km/h) | 02h 02m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $21.80 | $43.59 |
| Mid-grade | $4.25 | $24.58 | $49.16 |
| Premium | $4.65 | $26.90 | $53.80 |
| Diesel | $5.30 | $30.66 | $61.31 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.