How far is St. Louis, MO from De Soto, MO?
The driving distance from St. Louis, MO to De Soto, MO is about 46.5 miles (74.8 km), with a travel time of about 00h 58m by car.
- The straight-line flight distance is about 38.8 miles (62.5 km).
- For a round trip, plan for roughly 01h 57m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 00h 58m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place
Route Weather Snapshot
Check the forecast at both ends before you head out.
Scattered Rain Showers
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between St. Louis and De Soto.
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis and De Soto.
-
1
Start on Market Street
26 m · 4 sec · Market Street
-
2
Turn left onto South Tucker Boulevard
1.3 mi · 4 min · South Tucker Boulevard
-
3
Turn straight onto Gravois Avenue
1619 ft · 46 sec · Gravois Avenue
-
4
Take the ramp left toward I 55 South: Memphis
626 ft · 15 sec
-
5
Merge slight left
32.7 mi · 38 min
-
6
Take the exit slight right toward US 67 South: Farmington, Poplar Bluff
914 ft · 20 sec
-
7
Keep slight left
729 ft · 18 sec
-
8
Enter the roundabout and take exit 1 toward the route
9 m · 1 sec
-
9
Exit the roundabout
5.9 mi · 7 min
-
10
Take the exit slight right toward MO CC, MO 110: Olympian Village, De Soto
1350 ft · 32 sec
-
11
Turn right
4.1 mi · 5 min
-
12
Turn left onto Fountain City Road
1.2 km · 2 min · Fountain City Road
-
13
Turn left onto North Main Street
1.1 km · 1 min · North Main Street
-
14
Turn right onto Easton Street
133 m · 19 sec · Easton Street
-
15
Arrive at your destination
0 m · 1 sec · Easton Street
Car Route Details
A richer read on the saved driving route between St. Louis and De Soto.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Merge slight left
32.7 mi · 00h 38m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Scattered Rain Showers leaving St. Louis and Chance Showers And Thunderstorms near De Soto.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from St. Louis to De Soto?
The road trip is about 46.5 miles (74.8 km) and usually takes 00h 58m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Barnhart is a useful midpoint, sitting about 23.2 miles from St. Louis and 23.2 miles from De Soto.
How much longer is the road route than the straight-line distance?
The direct path is about 38.8 miles (62.5 km), while the road route adds roughly 7.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 4:32 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $6.18 one way or $12.37 round trip. Estimated CO2 is about 14.6 kg one way.
What should you check before leaving?
Before you leave, expect Scattered Rain Showers around St. Louis and Chance Showers And Thunderstorms near De Soto.
Stop Ideas Near Barnhart
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Barnhart.
Kirkwood
Gateway Transportation Center
Washington
Alton
Flight Path Map
This map shows the direct air route between St. Louis and De Soto. Straight-line distance: 38.86 mi (62.54 km).
#1 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
#2 De Soto
City in Jefferson County, Missouri
| Population | 6,340 |
| Coordinates | 38.1395000, -90.5551300 |
| Altitude | 160 |
| Country | United States |
End: De Soto (-90.55513, 38.1395)
Estimated Travel Time
Distance: 75 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 01h 32m |
| 40 mph (64.37 km/h) | 01h 09m |
| 50 mph (80.47 km/h) | 00h 55m |
| 60 mph (96.56 km/h) | 00h 46m |
| 70 mph (112.65 km/h) | 00h 39m |
| 80 mph (129 km/h) | 00h 34m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $6.18 | $12.37 |
| Mid-grade | $4.25 | $6.97 | $13.95 |
| Premium | $4.65 | $7.63 | $15.27 |
| Diesel | $5.30 | $8.70 | $17.40 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 31, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.