How far is Sioux City, IA from Muscatine, IA?
The driving distance from Sioux City, IA to Muscatine, IA is about 353.1 miles (568.2 km), with a travel time of about 06h 33m by car.
- The straight-line flight distance is about 285 miles (458.7 km).
- For a round trip, plan for roughly 13h 06m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 33m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Dallas County, Iowa, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers then Mostly Sunny
Chance Rain Showers then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Sioux City and Muscatine.
Turn-by-Turn Driving Directions
Step-by-step road directions between Sioux City and Muscatine.
-
1
Start on the route
35 m · 14 sec
-
2
Turn left onto 9th Street
990 ft · 46 sec · 9th Street
-
3
Turn right onto Court Street
1594 ft · 55 sec · Court Street
-
4
Turn left onto 5th Street
794 ft · 29 sec · 5th Street
-
5
Turn right onto Floyd Boulevard
1 km · 2 min · Floyd Boulevard
-
6
Take the ramp left toward I 29 South
1588 ft · 39 sec
-
7
Merge slight left
75.6 mi · 1 hr 22 min
-
8
Take the exit slight right toward I 880 East: Des Moines
1.2 km · 2 min
-
9
Continue straight
16 mi · 17 min
-
10
Keep slight left to continue on I 80 East: Des Moines
1.1 km · 44 sec
-
11
Merge slight right
94.9 mi · 1 hr 42 min
-
12
Keep slight right to continue on I 35, I 80 East: Chicago, Minneapolis, Kansas City
14.4 mi · 17 min
-
13
Keep slight left
133.7 mi · 2 hr 25 min
-
14
Take the exit slight right toward US 6 West, IA 38 South: Wilton, Muscatine
1254 ft · 31 sec
-
15
Turn right onto Rose Avenue
2.6 mi · 4 min · Rose Avenue
-
16
Continue on United States Highway 6
2583 ft · 44 sec · United States Highway 6
-
17
Continue on Grand Army of the Republic Highway
1.6 mi · 2 min · Grand Army of the Republic Highway
-
18
Continue on State Highway 38
9.5 mi · 15 min · State Highway 38
-
19
Continue on East 2nd Street
1 km · 1 min · East 2nd Street
-
20
Enter the roundabout and take exit 1 toward Mulberry Avenue
4 m · 1 sec · Mulberry Avenue
-
21
Exit the roundabout onto Mulberry Avenue
108 m · 16 sec · Mulberry Avenue
-
22
Turn left onto East 3rd Street
110 m · 18 sec · East 3rd Street
-
23
Turn right onto Walnut Street
48 m · 5 sec · Walnut Street
-
24
Arrive at your destination
0 m · 1 sec · Walnut Street
Car Route Details
A richer read on the saved driving route between Sioux City and Muscatine.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 35
Keep slight left
134 mi · 02h 25m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Chance Rain Showers then Mostly Sunny leaving Sioux City and Chance Rain Showers then Slight Chance Showers And Thunderstorms near Muscatine.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Sioux City to Muscatine?
The road trip is about 353.1 miles (568.2 km) and usually takes 06h 33m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
De Soto is a useful midpoint, sitting about 176.2 miles from Sioux City and 176.8 miles from Muscatine.
How much longer is the road route than the straight-line distance?
The direct path is about 285 miles (458.7 km), while the road route adds roughly 68.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $46.99 one way or $93.97 round trip. Estimated CO2 is about 110.7 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers then Mostly Sunny around Sioux City and Chance Rain Showers then Slight Chance Showers And Thunderstorms near Muscatine.
Stop Ideas Near De Soto
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to De Soto.
Osceola
Creston
Flight Path Map
This map shows the direct air route between Sioux City and Muscatine. Straight-line distance: 285.03 mi (458.71 km).
#1 Sioux City
The second most populous city in Iowa.
| Population | 82,651 |
| Coordinates | 42.4999900, -96.4003100 |
| Altitude | 366 |
| Country | United States |
#2 Muscatine
City in and county seat of Muscatine County, Iowa
| Population | 23,523 |
| Coordinates | 41.4244700, -91.0432100 |
| Altitude | 177 |
| Country | United States |
End: Muscatine (-91.04321, 41.42447)
Estimated Travel Time
Distance: 568 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 45m |
| 40 mph (64.37 km/h) | 08h 49m |
| 50 mph (80.47 km/h) | 07h 03m |
| 60 mph (96.56 km/h) | 05h 53m |
| 70 mph (112.65 km/h) | 05h 02m |
| 80 mph (129 km/h) | 04h 24m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $46.99 | $93.97 |
| Mid-grade | $4.25 | $52.99 | $105.98 |
| Premium | $4.65 | $57.99 | $115.98 |
| Diesel | $5.30 | $66.09 | $132.18 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Iowa · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.