How far is Port Saint Lucie, FL from Key West, FL?
The driving distance from Port Saint Lucie, FL to Key West, FL is about 272.9 miles (439.2 km), with a travel time of about 06h 04m by car.
- The straight-line flight distance is about 209.1 miles (336.5 km).
- For a round trip, plan for roughly 12h 09m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 04m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Miami-Dade County, Florida
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Slight Chance Showers And Thunderstorms
Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and Key West.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and Key West.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight left to continue on Miami, Florida's Turnpike South
2780 ft · 1 min
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7
Merge slight left onto Florida's Turnpike
95.5 mi · 1 hr 46 min · Florida's Turnpike
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8
Take the exit slight right toward Florida's Turnpike Toll South, Homestead
1197 ft · 20 sec · Homestead Extension of Florida's Turnpike
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9
Keep slight left to continue on Homestead Extension of Florida's Turnpike
46.9 mi · 54 min · Homestead Extension of Florida's Turnpike
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10
Keep slight left
2930 ft · 1 min
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11
Merge slight left onto Dixie Highway
19.2 mi · 27 min · Dixie Highway
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12
Continue on Overseas Highway
104.2 mi · 2 hr 43 min · Overseas Highway
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13
Turn right onto North Roosevelt Boulevard
2.4 mi · 6 min · North Roosevelt Boulevard
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14
Turn left onto George Street
1845 ft · 1 min · George Street
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15
Arrive at your destination
0 m · 1 sec · George Street
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and Key West.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Overseas Highway
Continue on Overseas Highway
104 mi · 02h 43m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny then Slight Chance Showers And Thunderstorms leaving Port Saint Lucie and Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms near Key West.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to Key West?
The road trip is about 272.9 miles (439.2 km) and usually takes 06h 04m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Goulds is a useful midpoint, sitting about 136.6 miles from Port Saint Lucie and 136.2 miles from Key West.
How much longer is the road route than the straight-line distance?
The direct path is about 209.1 miles (336.5 km), while the road route adds roughly 63.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $39.95 one way or $79.89 round trip. Estimated CO2 is about 85.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Slight Chance Showers And Thunderstorms around Port Saint Lucie and Slight Chance Showers And Thunderstorms then Chance Showers And Thunderstorms near Key West.
Stop Ideas Near Goulds
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Bistro & Martini Bar
Historic Homestead Town Hall Museum
Miami City Hall
Homestead Building & Zoning
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Goulds.
Miami Intermodal Center
Hollywood
Fort Lauderdale
Deerfield Beach
Flight Path Map
This map shows the direct air route between Port Saint Lucie and Key West. Straight-line distance: 209.08 mi (336.48 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 Key West
County seat city of Monroe County, Florida, United States; island in Florida Keys
| Population | 23,767 |
| Coordinates | 24.5552400, -81.7816300 |
| Altitude | 1 |
| Country | United States |
End: Key West (-81.78163, 24.55524)
Estimated Travel Time
Distance: 439 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 05m |
| 40 mph (64.37 km/h) | 06h 49m |
| 50 mph (80.47 km/h) | 05h 27m |
| 60 mph (96.56 km/h) | 04h 32m |
| 70 mph (112.65 km/h) | 03h 53m |
| 80 mph (129 km/h) | 03h 24m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $39.95 | $79.89 |
| Mid-grade | $4.60 | $44.26 | $88.52 |
| Premium | $4.90 | $47.15 | $94.30 |
| Diesel | $4.35 | $41.89 | $83.78 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 26, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.