How far is Port Saint Lucie, FL from Apalachicola, FL?
The driving distance from Port Saint Lucie, FL to Apalachicola, FL is about 412.1 miles (663.2 km), with a travel time of about 08h 23m by car.
- The straight-line flight distance is about 327.7 miles (527.4 km).
- For a round trip, plan for roughly 16h 46m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 08h 23m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Florida, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Port Saint Lucie and Apalachicola.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Saint Lucie and Apalachicola.
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1
Start on Southwest Carter Avenue
66 m · 11 sec · Southwest Carter Avenue
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2
Turn right onto Southeast Airoso Boulevard
1.6 mi · 3 min · Southeast Airoso Boulevard
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3
Turn right onto Southwest Port Saint Lucie Boulevard
1.3 km · 1 min · Southwest Port Saint Lucie Boulevard
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4
Turn left onto Southwest Bayshore Boulevard
560 ft · 22 sec · Southwest Bayshore Boulevard
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5
Take the ramp straight toward Florida's Turnpike Toll
2787 ft · 1 min
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6
Keep slight right to continue on Orlando, Florida's Turnpike North
1842 ft · 45 sec
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7
Merge slight left onto Florida's Turnpike
164.8 mi · 2 hr 57 min · Florida's Turnpike
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8
Keep slight left to continue on Florida's Turnpike
1281 ft · 16 sec · Florida's Turnpike
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9
Merge slight left
24.6 mi · 26 min
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10
Take the exit slight right toward US 27: Ocala, Williston
1342 ft · 37 sec
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11
Keep slight left to continue on US 27 North: Williston
90 m · 9 sec
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12
Merge slight right
48 mi · 1 hr 1 min
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13
Turn right onto Main Street
540 ft · 15 sec · Main Street
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14
Continue on Young Boulevard
66.5 mi · 1 hr 26 min · Young Boulevard
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15
Turn left onto Hampton Springs Avenue
54.4 mi · 1 hr 11 min · Hampton Springs Avenue
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16
Turn slight right onto Sopchoppy Highway
6.5 mi · 9 min · Sopchoppy Highway
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17
Keep slight left to continue on Sopchoppy Highway
10.5 mi · 15 min · Sopchoppy Highway
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18
Keep slight right
32.5 mi · 49 min
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19
Turn left onto Avenue C
139 m · 22 sec · Avenue C
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20
Turn right onto 5th Street
563 ft · 25 sec · 5th Street
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21
Arrive at your destination
0 m · 1 sec · 5th Street
Car Route Details
A richer read on the saved driving route between Port Saint Lucie and Apalachicola.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Florida's Turnpike
Merge slight left onto Florida's Turnpike
165 mi · 02h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Partly Sunny leaving Port Saint Lucie and Sunny near Apalachicola.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Saint Lucie to Apalachicola?
The road trip is about 412.1 miles (663.2 km) and usually takes 08h 23m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Williston is a useful midpoint, sitting about 206.1 miles from Port Saint Lucie and 205.9 miles from Apalachicola.
How much longer is the road route than the straight-line distance?
The direct path is about 327.7 miles (527.4 km), while the road route adds roughly 84.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $60.31 one way or $120.62 round trip. Estimated CO2 is about 129.2 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around Port Saint Lucie and Sunny near Apalachicola.
Stop Ideas Near Williston
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Williston.
Gainesville, Florida
Ocala, Florida
Waldo, Florida
Wildwood, Florida
Flight Path Map
This map shows the direct air route between Port Saint Lucie and Apalachicola. Straight-line distance: 327.73 mi (527.43 km).
#1 Port Saint Lucie
The second most populous city in St.
| Population | 209,715 |
| Coordinates | 27.2939300, -80.3503300 |
| Altitude | 5 |
| Country | United States |
#2 Apalachicola
County seat of Franklin County, Florida, United States
| Population | 2,372 |
| Coordinates | 29.7260000, -84.9856000 |
| Altitude | 4 |
| Country | United States |
End: Apalachicola (-84.9856, 29.726)
Estimated Travel Time
Distance: 663 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 43m |
| 40 mph (64.37 km/h) | 10h 18m |
| 50 mph (80.47 km/h) | 08h 14m |
| 60 mph (96.56 km/h) | 06h 52m |
| 70 mph (112.65 km/h) | 05h 53m |
| 80 mph (129 km/h) | 05h 08m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $60.31 | $120.62 |
| Mid-grade | $4.60 | $66.83 | $133.65 |
| Premium | $4.90 | $71.19 | $142.38 |
| Diesel | $4.35 | $63.25 | $126.50 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.