How far is Port Isabel, TX from San Antonio, TX?
The driving distance from Port Isabel, TX to San Antonio, TX is about 287.4 miles (462.6 km), with a travel time of about 04h 19m by car.
- The straight-line flight distance is about 244.4 miles (393.4 km).
- For a round trip, plan for roughly 08h 39m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 19m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy
Partly Sunny then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Port Isabel and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Port Isabel and San Antonio.
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1
Start on South Musina Street
985 ft · 33 sec · South Musina Street
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2
Turn left onto West Queen Isabella Boulevard
741 ft · 23 sec · West Queen Isabella Boulevard
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3
Turn straight onto State Highway 100
1 mi · 3 min · State Highway 100
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4
Turn left
14.1 mi · 15 min
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5
Take the exit slight right toward TX 550
936 ft · 23 sec
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6
Keep slight right to continue on TX 550
14 m · 1 sec
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7
Turn right onto State Highway 550
3.6 mi · 4 min · State Highway 550
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8
Continue straight
1.9 mi · 2 min
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9
Continue on I-169, TX 550 Toll
1.5 km · 59 sec · I-169, TX 550 Toll
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10
Continue on Interstate 169
3.6 mi · 4 min · Interstate 169
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11
Merge slight left onto North Expressway
2.2 mi · 2 min · North Expressway
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12
Continue on U.S. Highway 77
102 mi · 1 hr 53 min · U.S. Highway 77
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13
Keep slight right
623 ft · 8 sec
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14
Keep slight right
1.2 km · 2 min
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15
Turn left onto FM 772
1009 ft · 17 sec · FM 772
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16
Turn straight onto South 6th Street
4.4 mi · 7 min · South 6th Street
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17
Turn left onto West King Avenue
14.5 mi · 18 min · West King Avenue
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18
Take the ramp right
1 km · 2 min
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19
Merge slight left
54.2 mi · 1 hr 2 min
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20
Keep slight left to continue on Nueces Street
14.7 mi · 19 min · Nueces Street
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21
Continue straight
1199 ft · 16 sec
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22
Take the exit straight
68.8 mi · 1 hr 11 min
-
23
Take the exit slight right toward Commerce Street, Downtown, The Alamo
1358 ft · 33 sec
-
24
Turn straight onto Interstate 37 South
116 m · 12 sec · Interstate 37 South
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25
Turn left onto East Commerce Street
1.4 km · 2 min · East Commerce Street
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26
Turn left onto Military Plaza
119 m · 16 sec · Military Plaza
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27
Turn left onto Dolorosa Street
100 m · 8 sec · Dolorosa Street
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28
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Port Isabel and San Antonio.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
U.S. Highway 77
Continue on U.S. Highway 77
102 mi · 01h 53m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Cloudy leaving Port Isabel and Partly Sunny then Chance Showers And Thunderstorms near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Port Isabel to San Antonio?
The road trip is about 287.4 miles (462.6 km) and usually takes 04h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Kingsville is a useful midpoint, sitting about 145.2 miles from Port Isabel and 142.3 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 244.4 miles (393.4 km), while the road route adds roughly 43 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:20 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $38.32 one way or $76.64 round trip. Estimated CO2 is about 90.1 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy around Port Isabel and Partly Sunny then Chance Showers And Thunderstorms near San Antonio.
Stop Ideas Near Kingsville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Kingsville Water Department
Kleberg County District Clerk’s Office
K. C. Hall Of Alice
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kingsville.
Flight Path Map
This map shows the direct air route between Port Isabel and San Antonio. Straight-line distance: 244.48 mi (393.45 km).
#1 Port Isabel
City in Cameron County, Texas, United States
| Population | 6,226 |
| Coordinates | 26.0734100, -97.2085800 |
| Altitude | 2 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 463 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 34m |
| 40 mph (64.37 km/h) | 07h 11m |
| 50 mph (80.47 km/h) | 05h 44m |
| 60 mph (96.56 km/h) | 04h 47m |
| 70 mph (112.65 km/h) | 04h 06m |
| 80 mph (129 km/h) | 03h 35m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $38.32 | $76.64 |
| Mid-grade | $4.25 | $43.12 | $86.23 |
| Premium | $4.59 | $46.55 | $93.11 |
| Diesel | $3.99 | $40.49 | $80.98 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 29, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.