How far is Picayune, MS from Tupelo, MS?
The driving distance from Picayune, MS to Tupelo, MS is about 293.6 miles (472.5 km), with a travel time of about 04h 34m by car.
- The straight-line flight distance is about 264.1 miles (425 km).
- For a round trip, plan for roughly 09h 09m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 34m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in and the county seat of Lauderdale County, Mississippi, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers then Mostly Cloudy
Rain Showers Likely
Driving Route Map
The map below follows the saved road route between Picayune and Tupelo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Picayune and Tupelo.
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1
Start on East Canal Street
638 ft · 22 sec · East Canal Street
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2
Turn right
1.5 mi · 2 min
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3
Turn right onto Highway 43 North
1.1 mi · 2 min · Highway 43 North
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4
Continue on East Sycamore Road
1165 ft · 20 sec · East Sycamore Road
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5
Take the ramp left
1296 ft · 34 sec
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6
Merge slight left
141.1 mi · 2 hr 32 min
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7
Keep slight right to continue on I 59 North, I 20 East: Meridian, Tuscaloosa
9 mi · 11 min
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8
Take the exit slight right toward US 45 North: Macon
1383 ft · 47 sec
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9
Merge slight left
65.1 mi · 1 hr 14 min
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10
Keep slight left to continue on US Highway 45 Alternate
53 mi · 1 hr 4 min · US Highway 45 Alternate
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11
Continue on Martin Luther King Drive
18.1 mi · 21 min · Martin Luther King Drive
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12
Continue on Martin Luther King, Junior Drive
1.5 mi · 2 min · Martin Luther King, Junior Drive
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13
Take the exit slight right toward MS 6 East: Downtown Tupelo
2008 ft · 49 sec
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14
Keep slight left
52 m · 7 sec
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15
Turn left onto East Main Street
1.1 km · 2 min · East Main Street
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16
Turn right onto North Spring Street
70 m · 10 sec · North Spring Street
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17
Arrive at your destination
0 m · 1 sec · North Spring Street
Car Route Details
A richer read on the saved driving route between Picayune and Tupelo.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
East Sycamore Road
Merge slight left
141 mi · 02h 32m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Rain Showers then Mostly Cloudy leaving Picayune and Rain Showers Likely near Tupelo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Picayune to Tupelo?
The road trip is about 293.6 miles (472.5 km) and usually takes 04h 34m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Meridian is a useful midpoint, sitting about 146.4 miles from Picayune and 147.2 miles from Tupelo.
How much longer is the road route than the straight-line distance?
The direct path is about 264.1 miles (425 km), while the road route adds roughly 29.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 7:50 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $39.23 one way or $78.47 round trip. Estimated CO2 is about 92.1 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers then Mostly Cloudy around Picayune and Rain Showers Likely near Tupelo.
Stop Ideas Near Meridian
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Meridian.
Union Station
Laurel station
Thomasville, AL
Grove Hill, AL
Flight Path Map
This map shows the direct air route between Picayune and Tupelo. Straight-line distance: 264.06 mi (424.97 km).
#1 Picayune
City in Pearl River County, Mississippi, United States
| Population | 10,886 |
| Coordinates | 30.5255600, -89.6778800 |
| Altitude | 22 |
| Country | United States |
#2 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
End: North Spring Street (-88.704455, 34.258074)
Estimated Travel Time
Distance: 473 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 46m |
| 40 mph (64.37 km/h) | 07h 20m |
| 50 mph (80.47 km/h) | 05h 52m |
| 60 mph (96.56 km/h) | 04h 53m |
| 70 mph (112.65 km/h) | 04h 11m |
| 80 mph (129 km/h) | 03h 39m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $39.23 | $78.47 |
| Mid-grade | $4.26 | $44.12 | $88.25 |
| Premium | $4.63 | $47.92 | $95.83 |
| Diesel | $5.42 | $56.10 | $112.20 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.