How far is Tupelo, MS from Picayune, MS?
The driving distance from Tupelo, MS to Picayune, MS is about 291.7 miles (469.5 km), with a travel time of about 05h 32m by car.
- The straight-line flight distance is about 264.1 miles (425 km).
- For a round trip, plan for roughly 11h 04m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 32m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in and the county seat of Lauderdale County, Mississippi, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Rain Showers Likely
Chance Rain Showers then Mostly Cloudy
Driving Route Map
The map below follows the saved road route between Tupelo and Picayune.
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo and Picayune.
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1
Start on North Spring Street
21 m · 5 sec · North Spring Street
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2
Turn right onto Court Street
97 m · 16 sec · Court Street
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3
Turn right onto North Front Street
87 m · 15 sec · North Front Street
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4
Turn left onto East Main Street
2407 ft · 1 min · East Main Street
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5
Take the ramp straight
2248 ft · 56 sec
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6
Merge slight left onto Martin Luther King Drive
1.6 km · 1 min · Martin Luther King Drive
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7
Continue on Martin Luther King, Junior Drive
2.3 mi · 3 min · Martin Luther King, Junior Drive
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8
Continue on Martin Luther King Drive
7.7 mi · 9 min · Martin Luther King Drive
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9
Continue straight
1.4 mi · 2 min
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10
Continue straight
2.2 mi · 2 min
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11
Continue straight
1.5 mi · 2 min
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12
Continue straight
1.1 km · 49 sec
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13
Continue straight
1.4 mi · 2 min
-
14
Continue on US Highway 45 Alternate
54.7 mi · 1 hr 6 min · US Highway 45 Alternate
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15
Continue on US Highway 45 Aiternate
60.6 mi · 1 hr 9 min · US Highway 45 Aiternate
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16
Keep slight right
3.9 mi · 4 min
-
17
Take the exit slight right toward I 59 South, I 20 West: Meridian
2689 ft · 1 min
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18
Merge slight left
6.3 mi · 8 min
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19
Continue straight
1.8 mi · 2 min
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20
Keep slight left to continue on I 59 South: Laurel, New Orleans
141.7 mi · 2 hr 33 min
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21
Take the exit slight right toward MS 43: North Picayune
1355 ft · 33 sec
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22
Turn right onto Highway 43 North
1 mi · 2 min · Highway 43 North
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23
Turn straight
151 m · 22 sec
-
24
Turn left
1.5 mi · 2 min
-
25
Turn left onto East Canal Street
638 ft · 18 sec · East Canal Street
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26
Arrive at your destination
0 m · 1 sec · East Canal Street
Car Route Details
A richer read on the saved driving route between Tupelo and Picayune.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 59 South
Keep slight left to continue on I 59 South: Laurel, New Orleans
142 mi · 02h 33m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Rain Showers Likely leaving Tupelo and Chance Rain Showers then Mostly Cloudy near Picayune.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Tupelo to Picayune?
The road trip is about 291.7 miles (469.5 km) and usually takes 05h 32m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Meridian is a useful midpoint, sitting about 146.1 miles from Tupelo and 145.6 miles from Picayune.
How much longer is the road route than the straight-line distance?
The direct path is about 264.1 miles (425 km), while the road route adds roughly 27.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:56 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $38.97 one way or $77.94 round trip. Estimated CO2 is about 91.4 kg one way.
What should you check before leaving?
Before you leave, expect Rain Showers Likely around Tupelo and Chance Rain Showers then Mostly Cloudy near Picayune.
Stop Ideas Near Meridian
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Meridian.
Union Station
Laurel station
Thomasville, AL
Grove Hill, AL
Flight Path Map
This map shows the direct air route between Tupelo and Picayune. Straight-line distance: 264.06 mi (424.97 km).
#1 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
#2 Picayune
City in Pearl River County, Mississippi, United States
| Population | 10,886 |
| Coordinates | 30.5255600, -89.6778800 |
| Altitude | 22 |
| Country | United States |
End: Picayune (-89.67788, 30.52556)
Estimated Travel Time
Distance: 470 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 43m |
| 40 mph (64.37 km/h) | 07h 17m |
| 50 mph (80.47 km/h) | 05h 50m |
| 60 mph (96.56 km/h) | 04h 51m |
| 70 mph (112.65 km/h) | 04h 10m |
| 80 mph (129 km/h) | 03h 38m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $38.97 | $77.94 |
| Mid-grade | $4.26 | $43.83 | $87.65 |
| Premium | $4.63 | $47.59 | $95.18 |
| Diesel | $5.42 | $55.72 | $111.44 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.