How far is Odessa, MO from St. Louis, MO?
The driving distance from Odessa, MO to St. Louis, MO is about 213.1 miles (342.9 km), with a travel time of about 03h 11m by car.
- The straight-line flight distance is about 203.8 miles (328 km).
- For a round trip, plan for roughly 06h 23m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 11m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Callaway County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Showers And Thunderstorms
Mostly Sunny then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Odessa and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Odessa and St. Louis.
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1
Start on West Mason Street
9 m · 3 sec · West Mason Street
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2
Turn right onto South 2nd Street
2611 ft · 2 min · South 2nd Street
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3
At the end of the road, turn right onto West Old U.S. 40
3266 ft · 1 min · West Old U.S. 40
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4
Take the ramp straight toward I 70 East, US 40 East: Columbia
1094 ft · 27 sec
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5
Merge slight left onto Dwight D. Eisenhower Highway
31 mi · 33 min · Dwight D. Eisenhower Highway
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6
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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7
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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8
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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9
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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10
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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11
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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12
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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13
Merge slight left onto Avenue of the Saints
27.7 mi · 34 min · Avenue of the Saints
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14
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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15
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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16
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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17
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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18
Turn right onto Market Street
956 ft · 27 sec · Market Street
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19
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Odessa and St. Louis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
81 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Slight Chance Showers And Thunderstorms leaving Odessa and Mostly Sunny then Chance Showers And Thunderstorms near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Odessa to St. Louis?
The road trip is about 213.1 miles (342.9 km) and usually takes 03h 11m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Kingdom City is a useful midpoint, sitting about 106.4 miles from Odessa and 106.8 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 203.8 miles (328 km), while the road route adds roughly 9.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:36 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $28.36 one way or $56.72 round trip. Estimated CO2 is about 66.8 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Showers And Thunderstorms around Odessa and Mostly Sunny then Chance Showers And Thunderstorms near St. Louis.
Stop Ideas Near Kingdom City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kingdom City.
Jefferson City
Hermann
Washington
Sedalia
Flight Path Map
This map shows the direct air route between Odessa and St. Louis. Straight-line distance: 203.8 mi (327.99 km).
#1 Odessa
City in Missouri
| Population | 5,295 |
| Coordinates | 38.9991700, -93.9535600 |
| Altitude | 285 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 343 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 06m |
| 40 mph (64.37 km/h) | 05h 19m |
| 50 mph (80.47 km/h) | 04h 15m |
| 60 mph (96.56 km/h) | 03h 33m |
| 70 mph (112.65 km/h) | 03h 02m |
| 80 mph (129 km/h) | 02h 39m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $28.36 | $56.72 |
| Mid-grade | $4.25 | $31.98 | $63.97 |
| Premium | $4.65 | $35.00 | $70.00 |
| Diesel | $5.30 | $39.89 | $79.77 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 17, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.