How far is Odessa, MO from O'Fallon, MO?
The driving distance from Odessa, MO to O'Fallon, MO is about 181.1 miles (291.4 km), with a travel time of about 02h 41m by car.
- The straight-line flight distance is about 175.4 miles (282.3 km).
- For a round trip, plan for roughly 05h 23m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 41m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
The most populous city in the state of Missouri.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Cloudy
Driving Route Map
The map below follows the saved road route between Odessa and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between Odessa and O'Fallon.
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1
Start on West Mason Street
9 m · 5 sec · West Mason Street
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2
Turn right onto South 2nd Street
2611 ft · 2 min · South 2nd Street
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3
At the end of the road, turn right onto West Old U.S. 40
3266 ft · 1 min · West Old U.S. 40
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4
Take the ramp straight toward I 70 East, US 40 East: Columbia
1094 ft · 27 sec
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5
Merge slight left onto Dwight D. Eisenhower Highway
31 mi · 33 min · Dwight D. Eisenhower Highway
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6
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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7
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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8
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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9
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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10
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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11
Continue on Dwight D. Eisenhower Highway
88.2 mi · 1 hr 44 min · Dwight D. Eisenhower Highway
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12
Take the exit slight right toward MO K: O'Fallon
1765 ft · 43 sec
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13
Turn straight onto Drennen Parkway
46 m · 3 sec · Drennen Parkway
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14
Keep slight right to continue on Drennen Parkway
51 m · 6 sec · Drennen Parkway
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15
Turn slight left onto MO K: O'Fallon
19 m · 3 sec
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16
Continue on South Main Street
3115 ft · 2 min · South Main Street
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17
Turn right
8 m · 2 sec
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18
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Odessa and O'Fallon.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
88.2 mi · 01h 44m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Mostly Clear leaving Odessa and Partly Cloudy near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Odessa to O'Fallon?
The road trip is about 181.1 miles (291.4 km) and usually takes 02h 41m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Columbia is a useful midpoint, sitting about 90.5 miles from Odessa and 90.7 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 175.4 miles (282.3 km), while the road route adds roughly 5.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 1:06 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $24.10 one way or $48.19 round trip. Estimated CO2 is about 56.8 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Clear around Odessa and Partly Cloudy near O'Fallon.
Stop Ideas Near Columbia
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Columbia.
Jefferson City
Sedalia
Hermann
Flight Path Map
This map shows the direct air route between Odessa and O'Fallon. Straight-line distance: 175.42 mi (282.31 km).
#1 Odessa
City in Missouri
| Population | 5,295 |
| Coordinates | 38.9991700, -93.9535600 |
| Altitude | 285 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 291 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 02m |
| 40 mph (64.37 km/h) | 04h 31m |
| 50 mph (80.47 km/h) | 03h 37m |
| 60 mph (96.56 km/h) | 03h 01m |
| 70 mph (112.65 km/h) | 02h 35m |
| 80 mph (129 km/h) | 02h 15m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $24.10 | $48.19 |
| Mid-grade | $4.25 | $27.18 | $54.35 |
| Premium | $4.65 | $29.74 | $59.48 |
| Diesel | $5.30 | $33.89 | $67.79 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 29, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.