How far is Muleshoe, TX from San Antonio, TX?
The driving distance from Muleshoe, TX to San Antonio, TX is about 459 miles (738.7 km), with a travel time of about 06h 56m by car.
- The straight-line flight distance is about 414.3 miles (666.8 km).
- For a round trip, plan for roughly 13h 53m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 56m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Runnels County, Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Muleshoe and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Muleshoe and San Antonio.
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1
Start on North 1st Street
20 m · 7 sec · North 1st Street
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2
Turn left onto East American Boulevard
17.8 mi · 18 min · East American Boulevard
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3
Continue straight
8 mi · 8 min
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4
Continue straight
42 mi · 44 min
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5
Merge slight left onto Avenue Q
4 mi · 5 min · Avenue Q
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6
Continue on Slaton Road
4.8 mi · 6 min · Slaton Road
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7
Continue on East Highway 84
6.9 mi · 7 min · East Highway 84
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8
Continue on Trooper Jerry Don Davis Memorial Highway
4.5 mi · 5 min · Trooper Jerry Don Davis Memorial Highway
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9
Continue on East Highway 84
20 mi · 20 min · East Highway 84
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10
Continue on North US Highway 84
1 mi · 1 min · North US Highway 84
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11
Turn left onto East 15th Street
734 ft · 17 sec · East 15th Street
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12
Turn right onto Ralls Road
1863 ft · 38 sec · Ralls Road
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13
Turn straight onto North Avenue F
1.1 mi · 2 min · North Avenue F
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14
At the end of the road, turn left onto US Highway 84
73.9 mi · 1 hr 14 min · US Highway 84
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15
Keep slight left to continue on I 20 East, US 84 East: Abilene
6.5 mi · 7 min
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16
Take the exit slight right toward SH 70 South, SH 70 Business: Sweetwater, San Angelo
737 ft · 18 sec
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17
Turn slight left onto Southwest Georgia Avenue
624 ft · 17 sec · Southwest Georgia Avenue
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18
Turn right onto Lamar Street
1.2 km · 1 min · Lamar Street
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19
Continue on State Highway 70
10.4 mi · 11 min · State Highway 70
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20
Turn left onto State Highway 153
29.5 mi · 33 min · State Highway 153
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21
Turn right
12.3 mi · 13 min
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22
Turn left
6.3 mi · 7 min
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23
At the end of the road, turn right onto Hutchings Avenue
118 m · 18 sec · Hutchings Avenue
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24
Turn left onto South 7th Street
16.5 mi · 18 min · South 7th Street
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25
Continue on Grassmeyer Street
41.9 mi · 45 min · Grassmeyer Street
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26
Continue on Ellis Street
29.4 mi · 31 min · Ellis Street
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27
Take the exit left toward I 10 East: San Antonio
40 mi · 38 min
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28
Continue straight
54.3 mi · 55 min
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29
Keep slight right
17.4 mi · 20 min
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30
Keep slight right to continue on McDermott Freeway
1.7 mi · 2 min · McDermott Freeway
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31
Take the exit slight right toward Santa Rosa Street, Downtown
2505 ft · 1 min
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32
Turn straight onto North Pecos-La Trinidad
804 ft · 16 sec · North Pecos-La Trinidad
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33
Keep slight right to continue on North Pecos-La Trinidad
2963 ft · 1 min · North Pecos-La Trinidad
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34
Turn left onto Dolorosa Street
2582 ft · 56 sec · Dolorosa Street
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35
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Muleshoe and San Antonio.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
US Highway 84
At the end of the road, turn left onto US Highway 84
73.9 mi · 01h 14m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Muleshoe and Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Muleshoe to San Antonio?
The road trip is about 459 miles (738.7 km) and usually takes 06h 56m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Winters is a useful midpoint, sitting about 226.9 miles from Muleshoe and 232.1 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 414.3 miles (666.8 km), while the road route adds roughly 44.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $61.22 one way or $122.44 round trip. Estimated CO2 is about 144 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Muleshoe and Chance Showers And Thunderstorms then Slight Chance Showers And Thunderstorms near San Antonio.
Flight Path Map
This map shows the direct air route between Muleshoe and San Antonio. Straight-line distance: 414.35 mi (666.83 km).
#1 Muleshoe
City in Texas, USA
| Population | 4,822 |
| Coordinates | 34.2264700, -102.7238300 |
| Altitude | 1156 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 739 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 15h 17m |
| 40 mph (64.37 km/h) | 11h 28m |
| 50 mph (80.47 km/h) | 09h 10m |
| 60 mph (96.56 km/h) | 07h 39m |
| 70 mph (112.65 km/h) | 06h 33m |
| 80 mph (129 km/h) | 05h 43m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $61.22 | $122.44 |
| Mid-grade | $4.25 | $68.88 | $137.76 |
| Premium | $4.59 | $74.37 | $148.75 |
| Diesel | $3.99 | $64.69 | $129.37 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.